KRT84_HUMAN
ID KRT84_HUMAN Reviewed; 600 AA.
AC Q9NSB2; B2RA43; Q6ISB0; Q701L6;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Keratin, type II cuticular Hb4;
DE AltName: Full=Keratin-84;
DE Short=K84;
DE AltName: Full=Type II hair keratin Hb4;
DE AltName: Full=Type-II keratin Kb24;
GN Name=KRT84; Synonyms=KRTHB4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND VARIANT
RP ARG-446.
RC TISSUE=Scalp;
RX PubMed=10692104; DOI=10.1046/j.1523-1747.2000.00910.x;
RA Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J.;
RT "Characterization of a 300 kbp region of human DNA containing the type II
RT hair keratin.";
RL J. Invest. Dermatol. 114:464-472(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-600.
RC TISSUE=Scalp;
RX PubMed=15737194; DOI=10.1111/j.0022-202x.2004.23530.x;
RA Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J.;
RT "Characterization of new members of the human type II keratin gene family
RT and a general evaluation of the keratin gene domain on chromosome
RT 12q13.13.";
RL J. Invest. Dermatol. 124:536-544(2005).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- TISSUE SPECIFICITY: Expressed in the hair follicles.
CC {ECO:0000269|PubMed:10692104}.
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; Y19209; CAB76829.1; -; Genomic_DNA.
DR EMBL; AK314030; BAG36740.1; -; mRNA.
DR EMBL; AC078865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069647; AAH69647.1; -; mRNA.
DR EMBL; AJ628420; CAF31524.1; -; mRNA.
DR CCDS; CCDS8825.1; -.
DR RefSeq; NP_149034.2; NM_033045.3.
DR RefSeq; XP_011536637.1; XM_011538335.2.
DR AlphaFoldDB; Q9NSB2; -.
DR SMR; Q9NSB2; -.
DR BioGRID; 110088; 13.
DR IntAct; Q9NSB2; 8.
DR STRING; 9606.ENSP00000257951; -.
DR iPTMnet; Q9NSB2; -.
DR PhosphoSitePlus; Q9NSB2; -.
DR SwissPalm; Q9NSB2; -.
DR BioMuta; KRT84; -.
DR DMDM; 311033397; -.
DR jPOST; Q9NSB2; -.
DR MassIVE; Q9NSB2; -.
DR PaxDb; Q9NSB2; -.
DR PeptideAtlas; Q9NSB2; -.
DR PRIDE; Q9NSB2; -.
DR ProteomicsDB; 82523; -.
DR Antibodypedia; 43076; 78 antibodies from 19 providers.
DR DNASU; 3890; -.
DR Ensembl; ENST00000257951.3; ENSP00000257951.3; ENSG00000161849.3.
DR GeneID; 3890; -.
DR KEGG; hsa:3890; -.
DR MANE-Select; ENST00000257951.3; ENSP00000257951.3; NM_033045.4; NP_149034.2.
DR UCSC; uc001sah.2; human.
DR CTD; 3890; -.
DR GeneCards; KRT84; -.
DR HGNC; HGNC:6461; KRT84.
DR HPA; ENSG00000161849; Group enriched (lymphoid tissue, skin).
DR MIM; 602766; gene.
DR neXtProt; NX_Q9NSB2; -.
DR OpenTargets; ENSG00000161849; -.
DR PharmGKB; PA30250; -.
DR VEuPathDB; HostDB:ENSG00000161849; -.
DR eggNOG; ENOG502QWIE; Eukaryota.
DR GeneTree; ENSGT00940000162040; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; Q9NSB2; -.
DR OMA; EQKCARS; -.
DR OrthoDB; 904619at2759; -.
DR PhylomeDB; Q9NSB2; -.
DR TreeFam; TF317854; -.
DR PathwayCommons; Q9NSB2; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q9NSB2; -.
DR BioGRID-ORCS; 3890; 8 hits in 1062 CRISPR screens.
DR GenomeRNAi; 3890; -.
DR Pharos; Q9NSB2; Tdark.
DR PRO; PR:Q9NSB2; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NSB2; protein.
DR Bgee; ENSG00000161849; Expressed in placenta and 16 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0045095; C:keratin filament; IDA:UniProtKB.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; NAS:UniProtKB.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0001942; P:hair follicle development; NAS:UniProtKB.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR GO; GO:0035878; P:nail development; NAS:UniProtKB.
DR GO; GO:0045616; P:regulation of keratinocyte differentiation; IEA:Ensembl.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..600
FT /note="Keratin, type II cuticular Hb4"
FT /id="PRO_0000063700"
FT DOMAIN 165..476
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..165
FT /note="Head"
FT REGION 166..200
FT /note="Coil 1A"
FT REGION 201..210
FT /note="Linker 1"
FT REGION 211..311
FT /note="Coil 1B"
FT REGION 312..328
FT /note="Linker 12"
FT REGION 329..472
FT /note="Coil 2"
FT REGION 473..600
FT /note="Tail"
FT VARIANT 184
FT /note="R -> Q (in dbSNP:rs1613931)"
FT /id="VAR_018122"
FT VARIANT 198
FT /note="S -> N (in dbSNP:rs1732301)"
FT /id="VAR_030734"
FT VARIANT 206
FT /note="I -> V (in dbSNP:rs2245203)"
FT /id="VAR_018123"
FT VARIANT 446
FT /note="C -> R (in dbSNP:rs951773)"
FT /evidence="ECO:0000269|PubMed:10692104"
FT /id="VAR_018124"
FT VARIANT 497
FT /note="G -> R (in dbSNP:rs7297413)"
FT /id="VAR_030735"
FT CONFLICT 73
FT /note="I -> V (in Ref. 5; CAF31524)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="Q -> H (in Ref. 2; BAG36740)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="A -> T (in Ref. 5; CAF31524)"
FT /evidence="ECO:0000305"
FT CONFLICT 459
FT /note="D -> G (in Ref. 2; BAG36740)"
FT /evidence="ECO:0000305"
FT CONFLICT 548
FT /note="S -> G (in Ref. 5; CAF31524)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 600 AA; 64842 MW; 5266B0C4E5AE13F1 CRC64;
MSCRSYRVSS GHRVGNFSSC SAMTPQNLNR FRANSVSCWS GPGFRGLGSF GSRSVITFGS
YSPRIAAVGS RPIHCGVRFG AGCGMGFGDG RGVGLGPRAD SCVGLGFGAG SGIGYGFGGP
GFGYRVGGVG VPAAPSITAV TVNKSLLTPL NLEIDPNAQR VKKDEKEQIK TLNNKFASFI
DKVRFLEQQN KLLETKWSFL QEQKCIRSNL EPLFESYITN LRRQLEVLVS DQARLQAERN
HLQDVLEGFK KKYEEEVVCR ANAENEFVAL KKDVDAAFMN KSDLEANVDT LTQEIDFLKT
LYMEEIQLLQ SHISETSVIV KMDNSRDLNL DGIIAEVKAQ YEEVARRSRA DAEAWYQTKY
EEMQVTAGQH CDNLRNIRNE INELTRLIQR LKAEIEHAKA QRAKLEAAVA EAEQQGEATL
SDAKCKLADL ECALQQAKQD MARQLCEYQE LMNAKLGLDI EIATYRRLLE GEESRLCEGV
GPVNISVSSS RGGLVCGPEP LVAGSTLSRG GVTFSGSSSV CATSGVLASC GPSLGGARVA
PATGDLLSTG TRSGSMLISE ACVPSVPCPL PTQGGFSSCS GGRSSSVRFV STTTSCRTKY
