KRT87_MOUSE
ID KRT87_MOUSE Reviewed; 495 AA.
AC Q6IMF0; B2RTF5;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Keratin, type II cuticular 87;
DE AltName: Full=Keratin-87 {ECO:0000312|MGI:MGI:3665486};
DE Short=K87 {ECO:0000305};
GN Name=Krt87 {ECO:0000312|MGI:MGI:3665486};
GN Synonyms=Kb25 {ECO:0000303|PubMed:15085952},
GN Krt2-25 {ECO:0000312|MGI:MGI:3665486}, Krt83 {ECO:0000312|MGI:MGI:3665486};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:EDL04045.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAI39322.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:AAI39322.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000312|EMBL:DAA02058.1}
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; CAAA01196873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466550; EDL04045.1; -; Genomic_DNA.
DR EMBL; BC139321; AAI39322.1; -; mRNA.
DR EMBL; BC139322; AAI39323.1; -; mRNA.
DR EMBL; BK001583; DAA02058.1; -; mRNA.
DR CCDS; CCDS27852.1; -.
DR RefSeq; NP_001003668.2; NM_001003668.2.
DR AlphaFoldDB; Q6IMF0; -.
DR SMR; Q6IMF0; -.
DR BioGRID; 240429; 4.
DR STRING; 10090.ENSMUSP00000080613; -.
DR iPTMnet; Q6IMF0; -.
DR PhosphoSitePlus; Q6IMF0; -.
DR jPOST; Q6IMF0; -.
DR MaxQB; Q6IMF0; -.
DR PaxDb; Q6IMF0; -.
DR PeptideAtlas; Q6IMF0; -.
DR PRIDE; Q6IMF0; -.
DR ProteomicsDB; 263466; -.
DR DNASU; 406219; -.
DR Ensembl; ENSMUST00000081945; ENSMUSP00000080613; ENSMUSG00000047641.
DR GeneID; 406219; -.
DR KEGG; mmu:406219; -.
DR UCSC; uc007xte.2; mouse.
DR CTD; 406219; -.
DR MGI; MGI:3665486; Krt87.
DR VEuPathDB; HostDB:ENSMUSG00000047641; -.
DR eggNOG; ENOG502SK5S; Eukaryota.
DR GeneTree; ENSGT00940000154026; -.
DR HOGENOM; CLU_012560_5_0_1; -.
DR InParanoid; Q6IMF0; -.
DR OMA; CFSACGP; -.
DR OrthoDB; 557821at2759; -.
DR PhylomeDB; Q6IMF0; -.
DR TreeFam; TF317854; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 406219; 0 hits in 1 CRISPR screen.
DR PRO; PR:Q6IMF0; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6IMF0; protein.
DR Bgee; ENSMUSG00000047641; Expressed in lip and 14 other tissues.
DR Genevisible; Q6IMF0; MM.
DR GO; GO:0045095; C:keratin filament; ISO:MGI.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..495
FT /note="Keratin, type II cuticular 87"
FT /id="PRO_0000361692"
FT DOMAIN 111..422
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..111
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 112..146
FT /note="Coil 1A"
FT /evidence="ECO:0000255"
FT REGION 147..156
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 157..257
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT REGION 258..274
FT /note="Linker 12"
FT /evidence="ECO:0000255"
FT REGION 275..418
FT /note="Coil 2"
FT /evidence="ECO:0000255"
FT REGION 419..494
FT /note="Tail"
FT /evidence="ECO:0000255"
FT CONFLICT 456
FT /note="A -> V (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 495 AA; 54629 MW; 9523A541F0EF7231 CRC64;
MSCFSSRLGA SCGVRAFSCA SACGPRPGRC CISAAPYRGI SCYRGLSGGF GSRSVCGPFR
SGSCGRSFGY RSGGVCGPSP PCITTVSVNE SLLTPLNLEI DPNAQCVKHE EKEQIKCLNS
KFAAFIDKVR FLEQQNKLLE TKWQFYQNRK CCESNMEPLF EGYIEALRRE AECVEADSGR
LAAELNHVQE SMEGYKKRYE EEVALRATSE NEFVALKKDV DCAYLRKSDL EANAEALTQE
TDFLRQLYEE ETRLLHSHIS DTSVVVKMDN SRDLNMDCVV AEIKAQYDDI ASRSRAEAES
WYRTKCEEMK ATVIRHGETL RRTREEINEL NRMIQRLTAE IENAKCQNTK LEAAVTQSEQ
QGEAALTDAR CKLAELEGAL QKAKQDMACL LKEYQEVMNS KLGLDVEIIT YRRLLEGEEQ
RLCEGVGSVN VCVSSSRGGV TCGGLTYGTT PGRQIASGPS VTGGSITVMA PDSCSPCQPR
ASSFTCGSSR SVRFA
