ID   KRUC_SHEEP              Reviewed;         182 AA.
AC   P26372;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Keratin, ultra high-sulfur matrix protein;
DE   AltName: Full=UHS keratin;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair follicle;
RX   PubMed=1703541; DOI=10.1083/jcb.111.6.2587;
RA   McKinnon P.J., Powell B.C., Rogers G.E.;
RT   "Structure and expression of genes for a class of cysteine-rich proteins of
RT   the cuticle layers of differentiating wool and hair follicles.";
RL   J. Cell Biol. 111:2587-2600(1990).
CC   -!- FUNCTION: The keratin products of mammalian epidermal derivatives such
CC       as wool and hair consist of microfibrils embedded in a rigid matrix of
CC       other proteins. The matrix proteins include the high-sulfur and high-
CC       tyrosine keratins, having molecular weights of 6-20 kDa, whereas the
CC       microfibrils contain the larger, low-sulfur keratins (40-56 kDa).
CC   -!- TISSUE SPECIFICITY: Cuticle layers of differentiating wool follicles.
CC   -!- DEVELOPMENTAL STAGE: At a late stage of fiber differentiation.
CC   -!- DOMAIN: Mainly composed of Cys-rich (CR), Gly-rich (GR) and Ser-rich
CC       (SR) repeats.
CC   -!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}.
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DR   EMBL; X55294; CAA39006.1; -; mRNA.
DR   PIR; A36686; A36686.
DR   RefSeq; NP_001009807.1; NM_001009807.1.
DR   AlphaFoldDB; P26372; -.
DR   PRIDE; P26372; -.
DR   GeneID; 443402; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 3.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..182
FT                   /note="Keratin, ultra high-sulfur matrix protein"
FT                   /id="PRO_0000184110"
SQ   SEQUENCE   182 AA;  16101 MW;  9BDD4901FCB13295 CRC64;
     MGCSGCSGGC GSSCGGCGSR CGGCSSSCCV PVCCCKPVCC CVPACSCSSC GKGGCGSSCG
     GSKGGCGSCG GSKGGCGSCG GCGSSCCKPV CCCVPACSCS SCGKGGCGSC GGSKGGCGSC
     GGSKGGCGSC GGCGSGCGSS CCVPVCCCVP ACSCSSCGKG GCGSCGCSQS SCCVPVCCQR
     KI