ID   KRUP_MANSE              Reviewed;          76 AA.
AC   Q25515;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Protein krueppel;
DE   Flags: Fragment;
GN   Name=Kr;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Embryo;
RX   PubMed=8022829; DOI=10.1073/pnas.91.14.6634;
RA   Kraft R., Jaeckle H.;
RT   "Drosophila mode of metamerization in the embryogenesis of the lepidopteran
RT   insect Manduca sexta.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:6634-6638(1994).
CC   -!- FUNCTION: Krueppel is a gap class segmentation protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed initially in the central region of the
CC       blastoderm embryo.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; Z30278; CAA82952.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q25515; -.
DR   SMR; Q25515; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035282; P:segmentation; IEA:UniProtKB-KW.
DR   InterPro; IPR031243; Krueppel.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24390:SF151; PTHR24390:SF151; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Gap protein; Metal-binding; Nucleus;
KW   Repeat; Zinc; Zinc-finger.
FT   CHAIN           <1..>76
FT                   /note="Protein krueppel"
FT                   /id="PRO_0000046997"
FT   ZN_FING         11..33
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         39..61
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   NON_TER         1
FT   NON_TER         76
SQ   SEQUENCE   76 AA;  9105 MW;  F14B3454B876E1F3 CRC64;
     HERTHTGEKP FECSECHKRF TRDHHLKTHL RLHTGEKPYS CPHCPRHFVQ VANLRRHLRV
     HTGERPYACA RCPARF