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KRUP_MUSDO
ID   KRUP_MUSDO              Reviewed;          74 AA.
AC   Q01779;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Protein krueppel;
DE   Flags: Fragment;
GN   Name=Kr;
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1438276; DOI=10.1073/pnas.89.22.10782;
RA   Sommer R.J., Retzlaff M., Goerlich K., Sander K., Tautz D.;
RT   "Evolutionary conservation pattern of zinc-finger domains of Drosophila
RT   segmentation genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:10782-10786(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1685986; DOI=10.1242/dev.113.2.419;
RA   Sommer R.J., Tautz D.;
RT   "Segmentation gene expression in the housefly Musca domestica.";
RL   Development 113:419-430(1991).
CC   -!- FUNCTION: Krueppel is a gap class segmentation protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; L01602; AAA29297.1; -; Genomic_DNA.
DR   PIR; D61600; D61600.
DR   AlphaFoldDB; Q01779; -.
DR   SMR; Q01779; -.
DR   VEuPathDB; VectorBase:MDOA007462; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035282; P:segmentation; IEA:UniProtKB-KW.
DR   InterPro; IPR031243; Krueppel.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24390:SF151; PTHR24390:SF151; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Gap protein; Metal-binding; Nucleus;
KW   Repeat; Zinc; Zinc-finger.
FT   CHAIN           <1..>74
FT                   /note="Protein krueppel"
FT                   /id="PRO_0000046998"
FT   ZN_FING         <1..4
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         10..32
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         38..60
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         66..>74
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   NON_TER         1
FT   NON_TER         74
SQ   SEQUENCE   74 AA;  8891 MW;  6261804CD62E9E81 CRC64;
     ERTHTGEKPF ECPECHKRFT RDHHLKTHMR LHTGEKPYHC SHCDRQFVQV ANLRRHLRVH
     TGEKPYTCEI CDGK
 
 
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