ID   KS4_MESMA               Reviewed;          78 AA.
AC   Q5F1N4;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Toxin BmTxKS4 {ECO:0000303|PubMed:15452884};
DE   AltName: Full=KS3 toxin;
DE   Flags: Precursor;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND FUNCTION.
RC   TISSUE=Venom gland;
RX   PubMed=15452884; DOI=10.1002/jbt.20026;
RA   Sheng J., Xu X., Cao Z., Liu W., Wu Y., Zhu S., Zeng X., Jiang D., Mao X.,
RA   Liu H., Li W.-X., Wang T.;
RT   "Molecular cloning, genomic organization and functional characterization of
RT   a new short-chain potassium channel toxin-like peptide BmTxKS4 from Buthus
RT   martensii Karsch(BmK).";
RL   J. Biochem. Mol. Toxicol. 18:187-195(2004).
CC   -!- FUNCTION: Reversibly inhibits potassium channels.
CC       {ECO:0000269|PubMed:15452884}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000250}.
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DR   EMBL; AY278247; AAQ19046.1; -; mRNA.
DR   AlphaFoldDB; Q5F1N4; -.
DR   SMR; Q5F1N4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..32
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5000090613"
FT   CHAIN           33..78
FT                   /note="Toxin BmTxKS4"
FT                   /id="PRO_5000090614"
SQ   SEQUENCE   78 AA;  8856 MW;  1C82DBA1CDD4A250 CRC64;
     MKLKISFLIL VLFSVFFAIE GIIKWFPASV NGKGHSSCTN GLEMTEEDFC KMLCGIDGKL
     RESKCVDHWC YCSQILFP