ID   ARCA1_RHIME             Reviewed;         409 AA.
AC   Q92ZT2;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Arginine deiminase 1;
DE            Short=ADI 1;
DE            EC=3.5.3.6;
DE   AltName: Full=Arginine dihydrolase 1;
DE            Short=AD 1;
GN   Name=arcA1; OrderedLocusNames=RA0367; ORFNames=SMa0693;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OG   Plasmid pSymA (megaplasmid 1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481432; DOI=10.1073/pnas.161294798;
RA   Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F.,
RA   Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L.,
RA   Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C.,
RA   Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A.,
RA   Long S.R.;
RT   "Nucleotide sequence and predicted functions of the entire Sinorhizobium
RT   meliloti pSymA megaplasmid.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family. {ECO:0000305}.
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DR   EMBL; AE006469; AAK65025.1; -; Genomic_DNA.
DR   PIR; G95307; G95307.
DR   RefSeq; NP_435613.1; NC_003037.1.
DR   RefSeq; WP_010967359.1; NC_003037.1.
DR   AlphaFoldDB; Q92ZT2; -.
DR   SMR; Q92ZT2; -.
DR   EnsemblBacteria; AAK65025; AAK65025; SMa0693.
DR   GeneID; 61599193; -.
DR   KEGG; sme:SMa0693; -.
DR   PATRIC; fig|266834.11.peg.383; -.
DR   HOGENOM; CLU_052662_0_0_5; -.
DR   OMA; ERATMHL; -.
DR   UniPathway; UPA00254; UER00364.
DR   Proteomes; UP000001976; Plasmid pSymA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase; Plasmid; Reference proteome.
FT   CHAIN           1..409
FT                   /note="Arginine deiminase 1"
FT                   /id="PRO_0000182230"
FT   ACT_SITE        398
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   409 AA;  45656 MW;  FD6041A9EB85D1EE CRC64;
     MRTVGVHSEV GKLRTVMVCR PSLAHQRLTP GNCHDLLFDD VIWVHEAQKD HYDFVLKMEE
     RGVEVLELHD LLSDTLIDAE ARKFVLDRRV APNVMGSQIA ELMRPWMEEM DSRRLAAFLI
     GGISIADLPE GQGKALMASA FHSTQFVLPP IPNTLFQRDP SCWIYNGVTC NPMFWPARRA
     ETLIQRAVYK FHPSFKGAAF DIWWGDSDEQ FANATMEGGD VMPIGDGILL VGMGERTTYQ
     AVGQVAKALF KAGAATRVIG CLMPKSRAAM HLDTVFTFCD RDVVTLFADV VDQIRCYSLF
     PLDDEGNFEV RQEDRPMLEV VAEALGVDKL RTIATGGNTY EAEREQWDDG NNVVALEPGV
     VVAYDRNTYT NTLLRKAGIE VITIRGSELG RGRGGGHCMT CPIWREPTD