ID   KSTR2_MYCTO             Reviewed;         200 AA.
AC   P9WMB8; L0TD56; P96839; Q7D5A5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=HTH-type transcriptional repressor KstR2;
GN   Name=kstR2; OrderedLocusNames=MT3661;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Controls the expression of a small regulon that may play a
CC       role in the utilization of cholesterol. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR   EMBL; AE000516; AAK48020.1; -; Genomic_DNA.
DR   PIR; C70604; C70604.
DR   RefSeq; WP_003419329.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMB8; -.
DR   SMR; P9WMB8; -.
DR   EnsemblBacteria; AAK48020; AAK48020; MT3661.
DR   GeneID; 45427541; -.
DR   KEGG; mtc:MT3661; -.
DR   PATRIC; fig|83331.31.peg.3942; -.
DR   HOGENOM; CLU_069356_12_4_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR041490; KstR2_TetR_C.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF17932; TetR_C_24; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..200
FT                   /note="HTH-type transcriptional repressor KstR2"
FT                   /id="PRO_0000427331"
FT   DOMAIN          9..69
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   200 AA;  22906 MW;  E1B29D39CF4D955F CRC64;
     MDRVAGQVNS RRGELLELAA AMFAERGLRA TTVRDIADGA GILSGSLYHH FASKEEMVDE
     LLRGFLDWLF ARYRDIVDST ANPLERLQGL FMASFEAIEH HHAQVVIYQD EAQRLASQPR
     FSYIEDRNKQ QRKMWVDVLN QGIEEGYFRP DLDVDLVYRF IRDTTWVSVR WYRPGGPLTA
     QQVGQQYLAI VLGGITKEGV