ID   KSTR_MYCS2              Reviewed;         204 AA.
AC   A0R528; I7GG00;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=HTH-type transcriptional repressor KstR;
GN   Name=kstR; OrderedLocusNames=MSMEG_6042, MSMEI_5881;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
RN   [4]
RP   FUNCTION AS A TRANSCRIPTIONAL REPRESSOR.
RX   PubMed=17635188; DOI=10.1111/j.1365-2958.2007.05827.x;
RA   Kendall S.L., Withers M., Soffair C.N., Moreland N.J., Gurcha S.,
RA   Sidders B., Frita R., Ten Bokum A., Besra G.S., Lott J.S., Stoker N.G.;
RT   "A highly conserved transcriptional repressor controls a large regulon
RT   involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium
RT   tuberculosis.";
RL   Mol. Microbiol. 65:684-699(2007).
CC   -!- FUNCTION: Controls the expression of genes used for utilizing diverse
CC       lipids as energy sources. {ECO:0000269|PubMed:17635188}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AFP42314.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000480; ABK75291.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP42314.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_890266.1; NC_008596.1.
DR   AlphaFoldDB; A0R528; -.
DR   SMR; A0R528; -.
DR   STRING; 246196.MSMEI_5881; -.
DR   EnsemblBacteria; ABK75291; ABK75291; MSMEG_6042.
DR   EnsemblBacteria; AFP42314; AFP42314; MSMEI_5881.
DR   KEGG; msg:MSMEI_5881; -.
DR   KEGG; msm:MSMEG_6042; -.
DR   PATRIC; fig|246196.19.peg.5878; -.
DR   eggNOG; COG1309; Bacteria.
DR   OMA; VIEHTWH; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR041642; KstR_C.
DR   Pfam; PF17925; TetR_C_20; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..204
FT                   /note="HTH-type transcriptional repressor KstR"
FT                   /id="PRO_0000405029"
FT   DOMAIN          18..78
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        41..60
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   204 AA;  22571 MW;  1125BEBE034F88C2 CRC64;
     MTNVAVLSES ELGSEAQRER RKRILDATLA IASKGGYEAV QMRAVAERAD VAVGTLYRYF
     PSKVHLLVSA LGREFERIDA KTDRAALAGG TPYQRLNFMV GKLNRAMQRN PLLTEAMTRA
     FVFADASAAG EVDHVGKLMD SMFARAMSDG EPTEDQYHIA RVISDVWLSN LLAWLTRRAS
     ATDVSKRLDL AVRLLIGTEE QPKI