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KSTR_RHOJR
ID   KSTR_RHOJR              Reviewed;         212 AA.
AC   Q0S868;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=HTH-type transcriptional repressor KstR;
GN   Name=kstR; OrderedLocusNames=RHA1_ro04482;
OS   Rhodococcus jostii (strain RHA1).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=101510;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1;
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA   Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA   Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA   Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA   Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA   Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
RN   [2]
RP   FUNCTION IN CHOLESTEROL DEGRADATION.
RC   STRAIN=RHA1;
RX   PubMed=17264217; DOI=10.1073/pnas.0605728104;
RA   Van der Geize R., Yam K., Heuser T., Wilbrink M.H., Hara H., Anderton M.C.,
RA   Sim E., Dijkhuizen L., Davies J.E., Mohn W.W., Eltis L.D.;
RT   "A gene cluster encoding cholesterol catabolism in a soil actinomycete
RT   provides insight into Mycobacterium tuberculosis survival in macrophages.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1947-1952(2007).
CC   -!- FUNCTION: Controls the expression of genes used for utilizing diverse
CC       lipids as energy sources. {ECO:0000305|PubMed:17264217}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR   EMBL; CP000431; ABG96268.1; -; Genomic_DNA.
DR   RefSeq; WP_009477547.1; NC_008268.1.
DR   AlphaFoldDB; Q0S868; -.
DR   SMR; Q0S868; -.
DR   STRING; 101510.RHA1_ro04482; -.
DR   EnsemblBacteria; ABG96268; ABG96268; RHA1_ro04482.
DR   KEGG; rha:RHA1_ro04482; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_092076_1_0_11; -.
DR   OMA; VIEHTWH; -.
DR   Proteomes; UP000008710; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR041642; KstR_C.
DR   Pfam; PF17925; TetR_C_20; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..212
FT                   /note="HTH-type transcriptional repressor KstR"
FT                   /id="PRO_0000405030"
FT   DOMAIN          28..88
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        51..70
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   212 AA;  23427 MW;  9421D0553A64802E CRC64;
     MTTSSRSRSS TVAAATLGED DLSSNAQKER RKRILDATLA LASKGGYEAV QMRAVAERAD
     VAVGTLYRYF PSKVHLLVSA LAREFERIDS RGKNPPGRNP LERMQLILSQ ITRAMQRDPL
     LTEAMTRAFM FADASAAAEV DQVGKLMDRL FARAMTDTEP TEDQLAVARV ISDVWLSNLV
     AWLTRRSSAT DVANRLELTV ELLLGDGSRR PE
 
 
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