KSTR_RHOJR
ID KSTR_RHOJR Reviewed; 212 AA.
AC Q0S868;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=HTH-type transcriptional repressor KstR;
GN Name=kstR; OrderedLocusNames=RHA1_ro04482;
OS Rhodococcus jostii (strain RHA1).
OC Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX NCBI_TaxID=101510;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RHA1;
RX PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA Eltis L.D.;
RT "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT catabolic powerhouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
RN [2]
RP FUNCTION IN CHOLESTEROL DEGRADATION.
RC STRAIN=RHA1;
RX PubMed=17264217; DOI=10.1073/pnas.0605728104;
RA Van der Geize R., Yam K., Heuser T., Wilbrink M.H., Hara H., Anderton M.C.,
RA Sim E., Dijkhuizen L., Davies J.E., Mohn W.W., Eltis L.D.;
RT "A gene cluster encoding cholesterol catabolism in a soil actinomycete
RT provides insight into Mycobacterium tuberculosis survival in macrophages.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1947-1952(2007).
CC -!- FUNCTION: Controls the expression of genes used for utilizing diverse
CC lipids as energy sources. {ECO:0000305|PubMed:17264217}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000431; ABG96268.1; -; Genomic_DNA.
DR RefSeq; WP_009477547.1; NC_008268.1.
DR AlphaFoldDB; Q0S868; -.
DR SMR; Q0S868; -.
DR STRING; 101510.RHA1_ro04482; -.
DR EnsemblBacteria; ABG96268; ABG96268; RHA1_ro04482.
DR KEGG; rha:RHA1_ro04482; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_092076_1_0_11; -.
DR OMA; VIEHTWH; -.
DR Proteomes; UP000008710; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR041642; KstR_C.
DR Pfam; PF17925; TetR_C_20; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..212
FT /note="HTH-type transcriptional repressor KstR"
FT /id="PRO_0000405030"
FT DOMAIN 28..88
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT DNA_BIND 51..70
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 212 AA; 23427 MW; 9421D0553A64802E CRC64;
MTTSSRSRSS TVAAATLGED DLSSNAQKER RKRILDATLA LASKGGYEAV QMRAVAERAD
VAVGTLYRYF PSKVHLLVSA LAREFERIDS RGKNPPGRNP LERMQLILSQ ITRAMQRDPL
LTEAMTRAFM FADASAAAEV DQVGKLMDRL FARAMTDTEP TEDQLAVARV ISDVWLSNLV
AWLTRRSSAT DVANRLELTV ELLLGDGSRR PE