KT222_HUMAN
ID KT222_HUMAN Reviewed; 295 AA.
AC Q8N1A0; Q7Z368;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Keratin-like protein KRT222;
DE AltName: Full=Keratin-222;
DE AltName: Full=Keratin-222 pseudogene;
GN Name=KRT222; Synonyms=KA21, KRT222P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Cerebellum;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Adrenal cortex;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NOMENCLATURE.
RX PubMed=16831889; DOI=10.1083/jcb.200603161;
RA Schweizer J., Bowden P.E., Coulombe P.A., Langbein L., Lane E.B.,
RA Magin T.M., Maltais L., Omary M.B., Parry D.A.D., Rogers M.A., Wright M.W.;
RT "New consensus nomenclature for mammalian keratins.";
RL J. Cell Biol. 174:169-174(2006).
CC -!- INTERACTION:
CC Q8N1A0; P46379-2: BAG6; NbExp=3; IntAct=EBI-8473062, EBI-10988864;
CC Q8N1A0; P55212: CASP6; NbExp=3; IntAct=EBI-8473062, EBI-718729;
CC Q8N1A0; P06307: CCK; NbExp=3; IntAct=EBI-8473062, EBI-6624398;
CC Q8N1A0; P17066: HSPA6; NbExp=3; IntAct=EBI-8473062, EBI-355106;
CC Q8N1A0; P04792: HSPB1; NbExp=3; IntAct=EBI-8473062, EBI-352682;
CC Q8N1A0; Q9UMF0: ICAM5; NbExp=3; IntAct=EBI-8473062, EBI-6398041;
CC Q8N1A0; O60333-2: KIF1B; NbExp=3; IntAct=EBI-8473062, EBI-10975473;
CC Q8N1A0; O14901: KLF11; NbExp=3; IntAct=EBI-8473062, EBI-948266;
CC Q8N1A0; P13473-2: LAMP2; NbExp=3; IntAct=EBI-8473062, EBI-21591415;
CC Q8N1A0; O43933: PEX1; NbExp=3; IntAct=EBI-8473062, EBI-988601;
CC Q8N1A0; P62826: RAN; NbExp=3; IntAct=EBI-8473062, EBI-286642;
CC Q8N1A0; O76024: WFS1; NbExp=3; IntAct=EBI-8473062, EBI-720609;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N1A0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N1A0-2; Sequence=VSP_034744;
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- CAUTION: According to PubMed:16831889, it is a pseudogene.
CC {ECO:0000305}.
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DR EMBL; BX538083; CAD98007.1; -; mRNA.
DR EMBL; CH471152; EAW60672.1; -; Genomic_DNA.
DR EMBL; CH471152; EAW60673.1; -; Genomic_DNA.
DR EMBL; BC032815; AAH32815.1; -; mRNA.
DR CCDS; CCDS11371.1; -. [Q8N1A0-1]
DR RefSeq; NP_689562.1; NM_152349.2. [Q8N1A0-1]
DR AlphaFoldDB; Q8N1A0; -.
DR SMR; Q8N1A0; -.
DR BioGRID; 125916; 30.
DR IntAct; Q8N1A0; 15.
DR MINT; Q8N1A0; -.
DR STRING; 9606.ENSP00000377616; -.
DR GlyGen; Q8N1A0; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N1A0; -.
DR PhosphoSitePlus; Q8N1A0; -.
DR BioMuta; KRT222; -.
DR DMDM; 74750885; -.
DR EPD; Q8N1A0; -.
DR jPOST; Q8N1A0; -.
DR MassIVE; Q8N1A0; -.
DR PaxDb; Q8N1A0; -.
DR PeptideAtlas; Q8N1A0; -.
DR PRIDE; Q8N1A0; -.
DR ProteomicsDB; 71577; -. [Q8N1A0-1]
DR ProteomicsDB; 71578; -. [Q8N1A0-2]
DR Antibodypedia; 28682; 72 antibodies from 19 providers.
DR DNASU; 125113; -.
DR Ensembl; ENST00000394052.5; ENSP00000377616.3; ENSG00000213424.9. [Q8N1A0-1]
DR GeneID; 125113; -.
DR KEGG; hsa:125113; -.
DR MANE-Select; ENST00000394052.5; ENSP00000377616.3; NM_152349.3; NP_689562.1.
DR UCSC; uc002hvc.3; human. [Q8N1A0-1]
DR CTD; 125113; -.
DR DisGeNET; 125113; -.
DR GeneCards; KRT222; -.
DR HGNC; HGNC:28695; KRT222.
DR HPA; ENSG00000213424; Tissue enhanced (brain, retina).
DR neXtProt; NX_Q8N1A0; -.
DR OpenTargets; ENSG00000213424; -.
DR OpenTargets; ENSG00000264058; -.
DR PharmGKB; PA165432008; -.
DR VEuPathDB; HostDB:ENSG00000213424; -.
DR eggNOG; ENOG502QQ07; Eukaryota.
DR GeneTree; ENSGT00940000159655; -.
DR HOGENOM; CLU_101833_0_0_1; -.
DR InParanoid; Q8N1A0; -.
DR OMA; YHMQLQN; -.
DR OrthoDB; 966182at2759; -.
DR PhylomeDB; Q8N1A0; -.
DR TreeFam; TF332442; -.
DR PathwayCommons; Q8N1A0; -.
DR SignaLink; Q8N1A0; -.
DR BioGRID-ORCS; 125113; 13 hits in 1063 CRISPR screens.
DR ChiTaRS; KRT222; human.
DR GenomeRNAi; 125113; -.
DR Pharos; Q8N1A0; Tdark.
DR PRO; PR:Q8N1A0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8N1A0; protein.
DR Bgee; ENSG00000213424; Expressed in lateral nuclear group of thalamus and 115 other tissues.
DR ExpressionAtlas; Q8N1A0; baseline and differential.
DR Genevisible; Q8N1A0; HS.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Intermediate filament; Keratin;
KW Reference proteome.
FT CHAIN 1..295
FT /note="Keratin-like protein KRT222"
FT /id="PRO_0000344215"
FT DOMAIN 1..150
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT COILED 2..150
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..40
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_034744"
SQ SEQUENCE 295 AA; 34158 MW; 5A8A90215BA56563 CRC64;
MELSQLLNEI RANYEKILTR NQIETVLSTR IQLEEDISKK MDKDEEALKA AQAELKEARR
QWHHLQVEIE SLHAVERGLE NSLHASEQHY QMQLQDLETV IEGLEKELQE VRRGIEKQLQ
EHEMLLNTKM RLEQEIATYR HLLEKEEIRY YGCIQGGKKD KKPTTSRVGF VLPSAIINEI
SFTTKVPQKY ENENVETVTK QAILNGSIVK ESTEAHGTIQ TEKVDEVIKE WEGSFFKDNP
RLRKKSVSLR FDLHLAATDE GCLETKQDNL PDIEVRLIMR RSCSIPSIKP PSTAN
