KT222_MOUSE
ID KT222_MOUSE Reviewed; 294 AA.
AC Q8CCX5; Q3UU52; Q68FD8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Keratin-like protein KRT222;
DE AltName: Full=Keratin-222;
GN Name=Krt222;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CCX5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CCX5-2; Sequence=VSP_034745;
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE23776.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK031954; BAC27620.1; -; mRNA.
DR EMBL; AK138778; BAE23776.1; ALT_SEQ; mRNA.
DR EMBL; AL590991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC079890; AAH79890.1; -; mRNA.
DR CCDS; CCDS25375.1; -. [Q8CCX5-1]
DR CCDS; CCDS88251.1; -. [Q8CCX5-2]
DR RefSeq; NP_766534.1; NM_172946.2. [Q8CCX5-1]
DR RefSeq; XP_006533475.1; XM_006533412.3.
DR AlphaFoldDB; Q8CCX5; -.
DR SMR; Q8CCX5; -.
DR STRING; 10090.ENSMUSP00000099421; -.
DR PhosphoSitePlus; Q8CCX5; -.
DR MaxQB; Q8CCX5; -.
DR PaxDb; Q8CCX5; -.
DR PeptideAtlas; Q8CCX5; -.
DR PRIDE; Q8CCX5; -.
DR ProteomicsDB; 265030; -. [Q8CCX5-1]
DR ProteomicsDB; 265031; -. [Q8CCX5-2]
DR DNASU; 268481; -.
DR Ensembl; ENSMUST00000038214; ENSMUSP00000044561; ENSMUSG00000035849. [Q8CCX5-2]
DR Ensembl; ENSMUST00000103132; ENSMUSP00000099421; ENSMUSG00000035849. [Q8CCX5-1]
DR GeneID; 268481; -.
DR KEGG; mmu:268481; -.
DR UCSC; uc007lik.1; mouse. [Q8CCX5-1]
DR CTD; 125113; -.
DR MGI; MGI:2442728; Krt222.
DR VEuPathDB; HostDB:ENSMUSG00000035849; -.
DR eggNOG; ENOG502QQ07; Eukaryota.
DR GeneTree; ENSGT00940000159655; -.
DR HOGENOM; CLU_101833_0_0_1; -.
DR InParanoid; Q8CCX5; -.
DR OMA; YHMQLQN; -.
DR OrthoDB; 966182at2759; -.
DR PhylomeDB; Q8CCX5; -.
DR TreeFam; TF332442; -.
DR BioGRID-ORCS; 268481; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q8CCX5; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8CCX5; protein.
DR Bgee; ENSMUSG00000035849; Expressed in facial nucleus and 113 other tissues.
DR Genevisible; Q8CCX5; MM.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Intermediate filament; Keratin;
KW Reference proteome.
FT CHAIN 1..294
FT /note="Keratin-like protein KRT222"
FT /id="PRO_0000344216"
FT DOMAIN 1..150
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT COILED 1..151
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..40
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034745"
SQ SEQUENCE 294 AA; 34198 MW; 548B418C92C4F349 CRC64;
MELSQLLNEI RANYEQLLTR NQIETVLSTR IQLEEDITKK MDKDGEALKA AQAELKEARR
QCHHLQVEIE SLHAVERGLE NSLQASEQHY QMQLQDLESV IGRLERELQE VRRGIERQLR
EHEMLLNTKM RLEQEIATYR RLLEQEEIRY YGCIQGEKKE EKPTKSKVGF LLPSAIINEI
SFSTKVSQKY ENENMETVTK QAVVNRDVKE SAEAHGTIQT EKVDEVIKEW EGSFFKDNPR
LRKKSVSLRF DLHLAATDEG CLESRQDNLP DIEVRLIMRR SCSIPSIKPP PGTN
