KT33A_MOUSE
ID KT33A_MOUSE Reviewed; 404 AA.
AC Q8K0Y2; Q9D7C4;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Keratin, type I cuticular Ha3-I {ECO:0000250|UniProtKB:O76009};
DE AltName: Full=Hair keratin, type I Ha3-I;
DE AltName: Full=Keratin-33A {ECO:0000250|UniProtKB:O76009, ECO:0000312|EMBL:AAH29257.1};
DE Short=K33A;
GN Name=Krt33a {ECO:0000312|MGI:MGI:1919138};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAC29777.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC29777.1};
RC TISSUE=Neonatal skin {ECO:0000312|EMBL:BAC29777.1}, and
RC Tongue {ECO:0000312|EMBL:BAB26243.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:CAM22478.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAH29257.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH29257.1};
RC TISSUE=Salivary gland {ECO:0000312|EMBL:AAH29257.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AK009363; BAB26243.1; -; mRNA.
DR EMBL; AK037251; BAC29777.1; -; mRNA.
DR EMBL; AL592545; CAM22478.1; -; Genomic_DNA.
DR EMBL; CH466662; EDL02593.1; -; Genomic_DNA.
DR EMBL; BC029257; AAH29257.1; -; mRNA.
DR CCDS; CCDS25403.1; -.
DR RefSeq; NP_082259.2; NM_027983.3.
DR AlphaFoldDB; Q8K0Y2; -.
DR SMR; Q8K0Y2; -.
DR BioGRID; 215008; 1.
DR IntAct; Q8K0Y2; 1.
DR MINT; Q8K0Y2; -.
DR STRING; 10090.ENSMUSP00000018399; -.
DR PhosphoSitePlus; Q8K0Y2; -.
DR EPD; Q8K0Y2; -.
DR jPOST; Q8K0Y2; -.
DR PaxDb; Q8K0Y2; -.
DR PeptideAtlas; Q8K0Y2; -.
DR PRIDE; Q8K0Y2; -.
DR ProteomicsDB; 264880; -.
DR DNASU; 71888; -.
DR Ensembl; ENSMUST00000018399; ENSMUSP00000018399; ENSMUSG00000035592.
DR GeneID; 71888; -.
DR KEGG; mmu:71888; -.
DR UCSC; uc007lka.2; mouse.
DR CTD; 3883; -.
DR MGI; MGI:1919138; Krt33a.
DR VEuPathDB; HostDB:ENSMUSG00000035592; -.
DR eggNOG; ENOG502SNBF; Eukaryota.
DR GeneTree; ENSGT00940000153980; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; Q8K0Y2; -.
DR OMA; NACDTSI; -.
DR OrthoDB; 772040at2759; -.
DR PhylomeDB; Q8K0Y2; -.
DR TreeFam; TF332742; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 71888; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q8K0Y2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8K0Y2; protein.
DR Bgee; ENSMUSG00000035592; Expressed in lip and 15 other tissues.
DR Genevisible; Q8K0Y2; MM.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..404
FT /note="Keratin, type I cuticular Ha3-I"
FT /id="PRO_0000366205"
FT DOMAIN 56..367
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..56
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 57..91
FT /note="Coil 1A"
FT /evidence="ECO:0000255"
FT REGION 92..102
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 103..203
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT REGION 204..219
FT /note="Linker 12"
FT /evidence="ECO:0000255"
FT REGION 220..363
FT /note="Coil 2"
FT /evidence="ECO:0000255"
FT REGION 364..404
FT /note="Tail"
FT /evidence="ECO:0000255"
FT SITE 305
FT /note="Stutter"
FT /evidence="ECO:0000255"
FT CONFLICT 240
FT /note="R -> L (in Ref. 1; BAB26243)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 46137 MW; 15C54491027291DF CRC64;
MPYNCCLPAM SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG SFNGNEKETM
QFLNDRLASY MEKVRQLERE NAELECRIQE RNQQQDPLVC PAYQAYFRTI EELQQKILCG
KSENARLVVQ IDNAKLASDD FRTKYETELS LRQLVEADIN SLRRILDELT LCKSDLEAQV
ESLKEELLCL KQNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEALVETNR
REVEEWYTTQ TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH ELRNSLENTL
TESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDIRSRLE CEINTYRGLL
ESEDCKLPCN PCATTNACDK PIGPCVPNPC VTRPRCGPCN TFVR
