KT33A_PANTR
ID KT33A_PANTR Reviewed; 404 AA.
AC A5A6P3;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Keratin, type I cuticular Ha3-I {ECO:0000250|UniProtKB:O76009};
DE AltName: Full=Hair keratin, type I Ha3-I;
DE AltName: Full=Keratin-33A {ECO:0000250|UniProtKB:O76009};
DE Short=K33A;
GN Name=KRT33A {ECO:0000250|UniProtKB:O76009};
GN Synonyms=KRTHA3A {ECO:0000312|EMBL:BAF62416.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1] {ECO:0000312|EMBL:BAF62416.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skin {ECO:0000312|EMBL:BAF62416.1};
RX PubMed=17574350; DOI=10.1016/j.gene.2007.04.013;
RA Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I.,
RA Kusuda J., Gojobori T., Hashimoto K., Hirai M.;
RT "Mapping of chimpanzee full-length cDNAs onto the human genome unveils
RT large potential divergence of the transcriptome.";
RL Gene 399:1-10(2007).
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AB222171; BAF62416.1; -; mRNA.
DR RefSeq; NP_001104290.1; NM_001110820.1.
DR AlphaFoldDB; A5A6P3; -.
DR SMR; A5A6P3; -.
DR STRING; 9598.ENSPTRP00000015604; -.
DR PaxDb; A5A6P3; -.
DR PRIDE; A5A6P3; -.
DR GeneID; 743775; -.
DR KEGG; ptr:743775; -.
DR CTD; 3883; -.
DR eggNOG; ENOG502SNBF; Eukaryota.
DR InParanoid; A5A6P3; -.
DR OrthoDB; 772040at2759; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..404
FT /note="Keratin, type I cuticular Ha3-I"
FT /id="PRO_0000366206"
FT DOMAIN 56..367
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..56
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 57..91
FT /note="Coil 1A"
FT /evidence="ECO:0000255"
FT REGION 92..102
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 103..203
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT REGION 204..219
FT /note="Linker 12"
FT /evidence="ECO:0000255"
FT REGION 220..363
FT /note="Coil 2"
FT /evidence="ECO:0000255"
FT REGION 364..404
FT /note="Tail"
FT /evidence="ECO:0000255"
FT SITE 305
FT /note="Stutter"
FT /evidence="ECO:0000255"
SQ SEQUENCE 404 AA; 45917 MW; 3EFEDCD7D83B5F13 CRC64;
MSYSCGLPNL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM
QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC ASYQSYFKTI EELQQKILCT
KSENARLVVQ IDNAKLASDD FRTKYETELS LRQLVESDIN GLRRILDELT LCRSDLEAQV
ESLKEELLCL KQNHEQEVNT LRCQLGGRLN VEVDAAPAVD LNQVLNETRS QYEALVETNR
REVEQWFATQ TEELNKQVVS SSEQLQSYQV EIIELRRTVN ALEIELQAQH NLRDSLENTL
TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL
ESEDCKLPSN PCAITNACDK STGPCISNPC GPRARCGPCN TFGY
