KT33B_HUMAN
ID KT33B_HUMAN Reviewed; 404 AA.
AC Q14525; O76010;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 3.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Keratin, type I cuticular Ha3-II;
DE AltName: Full=Hair keratin, type I Ha3-II;
DE AltName: Full=Keratin-33B;
DE Short=K33B;
GN Name=KRT33B; Synonyms=HHA3-II, HKA3B, KRTHA3B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
RA Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
RT "Characterization of a 190-kilobase pair domain of human type I hair
RT keratin genes.";
RL J. Biol. Chem. 273:26683-26691(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 44-404.
RC TISSUE=Hair;
RX PubMed=7565656; DOI=10.1007/bf00990548;
RA Rogers M.A., Schweizer J., Kreig T., Winter H.;
RT "A novel human type I hair keratin gene: evidence for two keratin hHa3
RT isoforms.";
RL Mol. Biol. Rep. 20:155-161(1994).
RN [4]
RP SEQUENCE REVISION.
RA Rogers M.A.;
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q14525; Q9NYB9: ABI2; NbExp=3; IntAct=EBI-1049638, EBI-743598;
CC Q14525; Q13155: AIMP2; NbExp=3; IntAct=EBI-1049638, EBI-745226;
CC Q14525; P29972: AQP1; NbExp=3; IntAct=EBI-1049638, EBI-745213;
CC Q14525; P53367: ARFIP1; NbExp=3; IntAct=EBI-1049638, EBI-2808808;
CC Q14525; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-1049638, EBI-12006308;
CC Q14525; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-1049638, EBI-747505;
CC Q14525; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-1049638, EBI-1104933;
CC Q14525; P48643: CCT5; NbExp=3; IntAct=EBI-1049638, EBI-355710;
CC Q14525; P28329-3: CHAT; NbExp=3; IntAct=EBI-1049638, EBI-25837549;
CC Q14525; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-1049638, EBI-741032;
CC Q14525; P10606: COX5B; NbExp=3; IntAct=EBI-1049638, EBI-1053725;
CC Q14525; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-1049638, EBI-3867333;
CC Q14525; P17661: DES; NbExp=3; IntAct=EBI-1049638, EBI-1055572;
CC Q14525; G5E9A7: DMWD; NbExp=3; IntAct=EBI-1049638, EBI-10976677;
CC Q14525; O60941-5: DTNB; NbExp=3; IntAct=EBI-1049638, EBI-11984733;
CC Q14525; Q9H596: DUSP21; NbExp=3; IntAct=EBI-1049638, EBI-7357329;
CC Q14525; P48023: FASLG; NbExp=3; IntAct=EBI-1049638, EBI-495538;
CC Q14525; P22607: FGFR3; NbExp=3; IntAct=EBI-1049638, EBI-348399;
CC Q14525; O43559: FRS3; NbExp=3; IntAct=EBI-1049638, EBI-725515;
CC Q14525; P14136: GFAP; NbExp=3; IntAct=EBI-1049638, EBI-744302;
CC Q14525; Q8N9W4-2: GOLGA6L2; NbExp=3; IntAct=EBI-1049638, EBI-10268729;
CC Q14525; P06396: GSN; NbExp=3; IntAct=EBI-1049638, EBI-351506;
CC Q14525; P09211: GSTP1; NbExp=3; IntAct=EBI-1049638, EBI-353467;
CC Q14525; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-1049638, EBI-11956675;
CC Q14525; P56524-2: HDAC4; NbExp=3; IntAct=EBI-1049638, EBI-11953488;
CC Q14525; O14964: HGS; NbExp=6; IntAct=EBI-1049638, EBI-740220;
CC Q14525; P49639: HOXA1; NbExp=3; IntAct=EBI-1049638, EBI-740785;
CC Q14525; P01112: HRAS; NbExp=3; IntAct=EBI-1049638, EBI-350145;
CC Q14525; O43464: HTRA2; NbExp=3; IntAct=EBI-1049638, EBI-517086;
CC Q14525; P42858: HTT; NbExp=12; IntAct=EBI-1049638, EBI-466029;
CC Q14525; Q0VD86: INCA1; NbExp=3; IntAct=EBI-1049638, EBI-6509505;
CC Q14525; O60341: KDM1A; NbExp=4; IntAct=EBI-1049638, EBI-710124;
CC Q14525; O60333-2: KIF1B; NbExp=3; IntAct=EBI-1049638, EBI-10975473;
CC Q14525; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-1049638, EBI-949319;
CC Q14525; O14901: KLF11; NbExp=3; IntAct=EBI-1049638, EBI-948266;
CC Q14525; P04264: KRT1; NbExp=7; IntAct=EBI-1049638, EBI-298429;
CC Q14525; P35908: KRT2; NbExp=3; IntAct=EBI-1049638, EBI-1247312;
CC Q14525; P12035: KRT3; NbExp=3; IntAct=EBI-1049638, EBI-2430095;
CC Q14525; P19013: KRT4; NbExp=7; IntAct=EBI-1049638, EBI-2371606;
CC Q14525; P04259: KRT6B; NbExp=5; IntAct=EBI-1049638, EBI-740907;
CC Q14525; P48668: KRT6C; NbExp=3; IntAct=EBI-1049638, EBI-2564105;
CC Q14525; Q3SY84: KRT71; NbExp=3; IntAct=EBI-1049638, EBI-2952676;
CC Q14525; Q14CN4: KRT72; NbExp=3; IntAct=EBI-1049638, EBI-1221280;
CC Q14525; O95678: KRT75; NbExp=3; IntAct=EBI-1049638, EBI-2949715;
CC Q14525; Q8N1N4: KRT78; NbExp=5; IntAct=EBI-1049638, EBI-1056564;
CC Q14525; Q5XKE5: KRT79; NbExp=8; IntAct=EBI-1049638, EBI-2514135;
CC Q14525; P05787: KRT8; NbExp=5; IntAct=EBI-1049638, EBI-297852;
CC Q14525; Q6KB66-2: KRT80; NbExp=3; IntAct=EBI-1049638, EBI-11999246;
CC Q14525; Q9NSB4: KRT82; NbExp=3; IntAct=EBI-1049638, EBI-1045341;
CC Q14525; P78385: KRT83; NbExp=3; IntAct=EBI-1049638, EBI-10221390;
CC Q14525; P78386: KRT85; NbExp=3; IntAct=EBI-1049638, EBI-1049371;
CC Q14525; O43790: KRT86; NbExp=3; IntAct=EBI-1049638, EBI-9996498;
CC Q14525; P61968: LMO4; NbExp=3; IntAct=EBI-1049638, EBI-2798728;
CC Q14525; P00540: MOS; NbExp=3; IntAct=EBI-1049638, EBI-1757866;
CC Q14525; P19404: NDUFV2; NbExp=3; IntAct=EBI-1049638, EBI-713665;
CC Q14525; P07196: NEFL; NbExp=3; IntAct=EBI-1049638, EBI-475646;
CC Q14525; P35240: NF2; NbExp=3; IntAct=EBI-1049638, EBI-1014472;
CC Q14525; P29474: NOS3; NbExp=3; IntAct=EBI-1049638, EBI-1391623;
CC Q14525; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-1049638, EBI-741048;
CC Q14525; Q9BVL2: NUP58; NbExp=6; IntAct=EBI-1049638, EBI-2811583;
CC Q14525; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-1049638, EBI-11022007;
CC Q14525; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-1049638, EBI-2557469;
CC Q14525; P41219: PRPH; NbExp=3; IntAct=EBI-1049638, EBI-752074;
CC Q14525; P60891: PRPS1; NbExp=3; IntAct=EBI-1049638, EBI-749195;
CC Q14525; Q9ULW5: RAB26; NbExp=3; IntAct=EBI-1049638, EBI-958239;
CC Q14525; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-1049638, EBI-744023;
CC Q14525; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-1049638, EBI-396669;
CC Q14525; Q14D33: RTP5; NbExp=3; IntAct=EBI-1049638, EBI-10217913;
CC Q14525; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-1049638, EBI-11984663;
CC Q14525; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-1049638, EBI-748391;
CC Q14525; Q96ES7: SGF29; NbExp=3; IntAct=EBI-1049638, EBI-743117;
CC Q14525; Q92529: SHC3; NbExp=3; IntAct=EBI-1049638, EBI-79084;
CC Q14525; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-1049638, EBI-5235340;
CC Q14525; O75604: USP2; NbExp=3; IntAct=EBI-1049638, EBI-743272;
CC Q14525; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-1049638, EBI-2559305;
CC Q14525; O76024: WFS1; NbExp=3; IntAct=EBI-1049638, EBI-720609;
CC Q14525; Q9Y649; NbExp=3; IntAct=EBI-1049638, EBI-25900580;
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; Y16789; CAA76385.1; -; Genomic_DNA.
DR EMBL; BC009971; AAH09971.1; -; mRNA.
DR EMBL; X82634; CAA57956.1; -; mRNA.
DR CCDS; CCDS11389.1; -.
DR PIR; I37459; I37459.
DR RefSeq; NP_002270.1; NM_002279.4.
DR AlphaFoldDB; Q14525; -.
DR SMR; Q14525; -.
DR BioGRID; 110082; 89.
DR IntAct; Q14525; 88.
DR MINT; Q14525; -.
DR STRING; 9606.ENSP00000251646; -.
DR iPTMnet; Q14525; -.
DR PhosphoSitePlus; Q14525; -.
DR SwissPalm; Q14525; -.
DR BioMuta; KRT33B; -.
DR DMDM; 6686299; -.
DR jPOST; Q14525; -.
DR MassIVE; Q14525; -.
DR PaxDb; Q14525; -.
DR PeptideAtlas; Q14525; -.
DR PRIDE; Q14525; -.
DR ProteomicsDB; 60027; -.
DR Antibodypedia; 28829; 162 antibodies from 28 providers.
DR DNASU; 3884; -.
DR Ensembl; ENST00000251646.8; ENSP00000251646.3; ENSG00000131738.11.
DR Ensembl; ENST00000570596.1; ENSP00000459509.1; ENSG00000263012.1.
DR GeneID; 3884; -.
DR KEGG; hsa:3884; -.
DR MANE-Select; ENST00000251646.8; ENSP00000251646.3; NM_002279.5; NP_002270.1.
DR UCSC; uc002hwl.4; human.
DR CTD; 3884; -.
DR GeneCards; KRT33B; -.
DR HGNC; HGNC:6451; KRT33B.
DR HPA; ENSG00000131738; Tissue enriched (skin).
DR MIM; 602762; gene.
DR neXtProt; NX_Q14525; -.
DR OpenTargets; ENSG00000131738; -.
DR PharmGKB; PA30240; -.
DR VEuPathDB; HostDB:ENSG00000131738; -.
DR eggNOG; ENOG502SNBF; Eukaryota.
DR GeneTree; ENSGT00940000163841; -.
DR InParanoid; Q14525; -.
DR OMA; ACNISAN; -.
DR OrthoDB; 772040at2759; -.
DR PhylomeDB; Q14525; -.
DR TreeFam; TF332742; -.
DR PathwayCommons; Q14525; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q14525; -.
DR BioGRID-ORCS; 3884; 7 hits in 1069 CRISPR screens.
DR ChiTaRS; KRT33B; human.
DR GeneWiki; KRT33B; -.
DR GenomeRNAi; 3884; -.
DR Pharos; Q14525; Tbio.
DR PRO; PR:Q14525; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q14525; protein.
DR Bgee; ENSG00000131738; Expressed in prefrontal cortex and 46 other tissues.
DR Genevisible; Q14525; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0007568; P:aging; IDA:UniProtKB.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0042633; P:hair cycle; IDA:UniProtKB.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..404
FT /note="Keratin, type I cuticular Ha3-II"
FT /id="PRO_0000063689"
FT DOMAIN 56..367
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..56
FT /note="Head"
FT REGION 57..91
FT /note="Coil 1A"
FT REGION 92..102
FT /note="Linker 1"
FT REGION 103..203
FT /note="Coil 1B"
FT REGION 204..219
FT /note="Linker 12"
FT REGION 220..363
FT /note="Coil 2"
FT REGION 364..404
FT /note="Tail"
FT SITE 305
FT /note="Stutter"
FT CONFLICT 76..77
FT /note="QL -> HV (in Ref. 3; CAA57956)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 46214 MW; 54B5F7BEDC34619F CRC64;
MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG SFNGSEKETM
QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCS
KSENARLVVQ IDNAKLAADD FRTKYQTEQS LRQLVESDIN SLRRILDELT LCRSDLEAQM
ESLKEELLSL KQNHEQEVNT LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR
REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL
ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN TFGY
