KT33B_MOUSE
ID KT33B_MOUSE Reviewed; 404 AA.
AC Q61897; A2A5X8;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Keratin, type I cuticular Ha3-II;
DE AltName: Full=Hair keratin, type I Ha3;
DE AltName: Full=Keratin, type I cuticular Ha3;
DE AltName: Full=Keratin-33B;
DE Short=K33B;
GN Name=Krt33b; Synonyms=Hka3, Krt1-3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 82-404, AND TISSUE SPECIFICITY.
RC STRAIN=NMRI; TISSUE=Tail epidermis;
RX PubMed=7514534; DOI=10.1006/excr.1994.1134;
RA Winter H., Siry P., Tobiasch E., Schweizer J.;
RT "Sequence and expression of murine type I hair keratins mHa2 and mHa3.";
RL Exp. Cell Res. 212:190-200(1994).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Expressed strongly in cortex cells in newborn back
CC skin and in the central unit of the lingual filiform papillae.
CC {ECO:0000269|PubMed:7514534}.
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AL592545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466662; EDL02591.1; -; Genomic_DNA.
DR EMBL; X75650; CAA53305.1; -; mRNA.
DR CCDS; CCDS48928.1; -.
DR PIR; I48667; I48667.
DR RefSeq; NP_038598.1; NM_013570.1.
DR AlphaFoldDB; Q61897; -.
DR SMR; Q61897; -.
DR BioGRID; 201026; 1.
DR STRING; 10090.ENSMUSP00000073552; -.
DR PhosphoSitePlus; Q61897; -.
DR jPOST; Q61897; -.
DR MaxQB; Q61897; -.
DR PaxDb; Q61897; -.
DR PeptideAtlas; Q61897; -.
DR PRIDE; Q61897; -.
DR ProteomicsDB; 265050; -.
DR DNASU; 16671; -.
DR Ensembl; ENSMUST00000073890; ENSMUSP00000073552; ENSMUSG00000057723.
DR GeneID; 16671; -.
DR KEGG; mmu:16671; -.
DR UCSC; uc007lkb.2; mouse.
DR CTD; 3884; -.
DR MGI; MGI:1309991; Krt33b.
DR VEuPathDB; HostDB:ENSMUSG00000057723; -.
DR eggNOG; ENOG502SNBF; Eukaryota.
DR GeneTree; ENSGT00940000153980; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; Q61897; -.
DR OMA; ESHIREW; -.
DR OrthoDB; 772040at2759; -.
DR PhylomeDB; Q61897; -.
DR TreeFam; TF332742; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 16671; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Krt33b; mouse.
DR PRO; PR:Q61897; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q61897; protein.
DR Bgee; ENSMUSG00000057723; Expressed in skin of snout and 20 other tissues.
DR Genevisible; Q61897; MM.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..404
FT /note="Keratin, type I cuticular Ha3-II"
FT /id="PRO_0000063690"
FT DOMAIN 56..367
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..56
FT /note="Head"
FT REGION 57..91
FT /note="Coil 1A"
FT REGION 92..102
FT /note="Linker 1"
FT REGION 103..203
FT /note="Coil 1B"
FT REGION 204..219
FT /note="Linker 12"
FT REGION 220..363
FT /note="Coil 2"
FT REGION 364..404
FT /note="Tail"
FT SITE 305
FT /note="Stutter"
FT CONFLICT 87
FT /note="K -> R (in Ref. 3; CAA53305)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="G -> S (in Ref. 3; CAA53305)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="G -> A (in Ref. 3; CAA53305)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="D -> E (in Ref. 3; CAA53305)"
FT /evidence="ECO:0000305"
FT CONFLICT 153..154
FT /note="QL -> HV (in Ref. 3; CAA53305)"
FT /evidence="ECO:0000305"
FT CONFLICT 204
FT /note="Q -> R (in Ref. 3; CAA53305)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 45864 MW; 0734BC6D69D820BB CRC64;
MPYNCCLPAM SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG SFNGNERETM
QFLNDRLASY MEKVRQLERE NAELECKIQE RNQQQDPLVC PAYQAYFRTI EELQQKILCG
KSENGRLVVQ IDNAKLAADD FRTKYESELS LRQLVESDLN GLRRILDELT LCKSDLEAQV
ESLRQELLCL KQNHEEEVNT LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEALVETNR
REVEEWFTTQ TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH SMRNSLENTL
AESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDVKARLE CEINTYRGLL
ESEDCKLPCN PCATTNACDK PIGPCVTNPC VTRSRCGPCN SFGC
