ARCA_BACC4
ID ARCA_BACC4 Reviewed; 410 AA.
AC B7H7F6;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Arginine deiminase {ECO:0000255|HAMAP-Rule:MF_00242};
DE Short=ADI {ECO:0000255|HAMAP-Rule:MF_00242};
DE EC=3.5.3.6 {ECO:0000255|HAMAP-Rule:MF_00242};
DE AltName: Full=Arginine dihydrolase {ECO:0000255|HAMAP-Rule:MF_00242};
DE Short=AD {ECO:0000255|HAMAP-Rule:MF_00242};
GN Name=arcA {ECO:0000255|HAMAP-Rule:MF_00242};
GN OrderedLocusNames=BCB4264_A0420;
OS Bacillus cereus (strain B4264).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=405532;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B4264;
RA Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA Ravel J., Sutton G.;
RT "Genome sequence of Bacillus cereus B4264.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00242};
CC -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC {ECO:0000255|HAMAP-Rule:MF_00242}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00242}.
CC -!- SIMILARITY: Belongs to the arginine deiminase family.
CC {ECO:0000255|HAMAP-Rule:MF_00242}.
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DR EMBL; CP001176; ACK60913.1; -; Genomic_DNA.
DR RefSeq; WP_000682331.1; NZ_VEHB01000009.1.
DR AlphaFoldDB; B7H7F6; -.
DR SMR; B7H7F6; -.
DR EnsemblBacteria; ACK60913; ACK60913; BCB4264_A0420.
DR GeneID; 67505103; -.
DR KEGG; bcb:BCB4264_A0420; -.
DR HOGENOM; CLU_052662_0_1_9; -.
DR OMA; ERATMHL; -.
DR UniPathway; UPA00254; UER00364.
DR Proteomes; UP000007096; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR HAMAP; MF_00242; Arg_deiminase; 1.
DR InterPro; IPR003876; Arg_deiminase.
DR PIRSF; PIRSF006356; Arg_deiminase; 1.
DR PRINTS; PR01466; ARGDEIMINASE.
DR TIGRFAMs; TIGR01078; arcA; 1.
PE 3: Inferred from homology;
KW Arginine metabolism; Cytoplasm; Hydrolase.
FT CHAIN 1..410
FT /note="Arginine deiminase"
FT /id="PRO_1000119035"
FT ACT_SITE 400
FT /note="Amidino-cysteine intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00242"
SQ SEQUENCE 410 AA; 46880 MW; 3D3AE8489168BD73 CRC64;
MKHPIHVTSE IGELQTVLLK RPGKEVENLT PDYLQQLLFD DIPYLPIIQK EHDYFAQTLR
NRGVEVLYLE KLAAEALVDK KLREEFVDRI LKEGQADVNV AHQTLKEYLL SFSNEELIQK
IMGGVRKNEI ETSKKTHLYE LMEDHYPFYL DPMPNLYFTR DPAASVGDGL TINKMREPAR
RRESLFMEYI IKYHPRFAKH NVPIWLDRDY KFPIEGGDEL ILNEETIAIG VSARTSAKAI
ERLAKNLFSR QNKIKKVLAI EIPKCRAFMH LDTVFTMVDY DKFTIHPAIQ GPKGNMNIYI
LEKGSDEETL KITHRTSLME ALKEVLGLSE LVLIPCGGGD VIASAREQWN DGSNTLAIAP
GVVVTYDRNY VSNTLLREHG IEVIEVLSSE LSRGRGGPRC MSMPIVRKDI