ID   KTAP2_AEDAE             Reviewed;         132 AA.
AC   Q1HQF8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protein KRTCAP2 homolog;
DE   AltName: Full=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2;
DE            Short=Oligosaccharyl transferase subunit KCP2;
GN   ORFNames=AAEL007634;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=17204158; DOI=10.1186/1471-2164-8-6;
RA   Ribeiro J.M.C., Arca B., Lombardo F., Calvo E., Phan V.M., Chandra P.K.,
RA   Wikel S.K.;
RT   "An annotated catalogue of salivary gland transcripts in the adult female
RT   mosquito, Aedes aegypti.";
RL   BMC Genomics 8:6-6(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that
CC       catalyzes the initial transfer of a defined glycan
CC       (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-
CC       pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr
CC       consensus motif in nascent polypeptide chains, the first step in
CC       protein N-glycosylation. N-glycosylation occurs cotranslationally and
CC       the complex associates with the Sec61 complex at the channel-forming
CC       translocon complex that mediates protein translocation across the
CC       endoplasmic reticulum (ER). All subunits are required for a maximal
CC       enzyme activity. {ECO:0000250|UniProtKB:Q8N6L1}.
CC   -!- SUBUNIT: Component of the oligosaccharyltransferase (OST) complex.
CC       {ECO:0000250|UniProtKB:P86229}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the KRTCAP2 family. {ECO:0000305}.
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DR   EMBL; DQ440486; ABF18519.1; -; mRNA.
DR   EMBL; CH477454; EAT40648.1; -; Genomic_DNA.
DR   RefSeq; XP_001658521.1; XM_001658471.1.
DR   AlphaFoldDB; Q1HQF8; -.
DR   STRING; 7159.AAEL007634-PA; -.
DR   GeneID; 5569432; -.
DR   KEGG; aag:5569432; -.
DR   VEuPathDB; VectorBase:AAEL007634; -.
DR   eggNOG; KOG4615; Eukaryota.
DR   HOGENOM; CLU_109648_2_0_1; -.
DR   InParanoid; Q1HQF8; -.
DR   OMA; EMVVFGQ; -.
DR   OrthoDB; 1561955at2759; -.
DR   PhylomeDB; Q1HQF8; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018614; KRTCAP2.
DR   PANTHER; PTHR32001; PTHR32001; 1.
DR   Pfam; PF09775; Keratin_assoc; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..132
FT                   /note="Protein KRTCAP2 homolog"
FT                   /id="PRO_0000327901"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   132 AA;  14126 MW;  78131EA49C8134B5 CRC64;
     MAVPTSVSLV LASVTAVLIF SAMQMYKPLI ASSQMATVFG GFLGSWLFIL SLTAVSNLEA
     VVLGKGFQAK LFPEVAFCLI GSLFACGMVH RVCATTCILF SVAALYYINR ISQKVHNAPV
     PVDTYAGKKK KK