ID   KTAP2_IXOSC             Reviewed;         135 AA.
AC   Q5Q995;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Protein KRTCAP2 homolog;
DE   AltName: Full=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2;
DE            Short=Oligosaccharyl transferase subunit KCP2;
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=16431279; DOI=10.1016/j.ibmb.2005.11.005;
RA   Ribeiro J.M.C., Alarcon-Chaidez F., Francischetti I.M.B., Mans B.J.,
RA   Mather T.N., Valenzuela J.G., Wikel S.K.;
RT   "An annotated catalog of salivary gland transcripts from Ixodes scapularis
RT   ticks.";
RL   Insect Biochem. Mol. Biol. 36:111-129(2006).
CC   -!- FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that
CC       catalyzes the initial transfer of a defined glycan
CC       (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-
CC       pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr
CC       consensus motif in nascent polypeptide chains, the first step in
CC       protein N-glycosylation. N-glycosylation occurs cotranslationally and
CC       the complex associates with the Sec61 complex at the channel-forming
CC       translocon complex that mediates protein translocation across the
CC       endoplasmic reticulum (ER). All subunits are required for a maximal
CC       enzyme activity. {ECO:0000250|UniProtKB:Q8N6L1}.
CC   -!- SUBUNIT: Component of the oligosaccharyltransferase (OST) complex.
CC       {ECO:0000250|UniProtKB:P86229}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the KRTCAP2 family. {ECO:0000305}.
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DR   EMBL; AY775809; AAV80776.1; -; mRNA.
DR   AlphaFoldDB; Q5Q995; -.
DR   VEuPathDB; VectorBase:ISCI008252; -.
DR   VEuPathDB; VectorBase:ISCW008252; -.
DR   HOGENOM; CLU_109648_2_0_1; -.
DR   Proteomes; UP000001555; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018614; KRTCAP2.
DR   PANTHER; PTHR32001; PTHR32001; 1.
DR   Pfam; PF09775; Keratin_assoc; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..135
FT                   /note="Protein KRTCAP2 homolog"
FT                   /id="PRO_0000327904"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   135 AA;  14326 MW;  C01D1753CF920DC5 CRC64;
     MAVSSGTSGM LATCLFMLLF ATMQIYKSQL TSSQPMAIVG GFLGSVLFIL ILTAISNFET
     HFFGRNFQTK LIPEVVIALV IAMAASGMVH RVCITTCLIF SIVALYYVSR ISIKVHGSGA
     GTATAIPVTK GKKGK