KTBL1_HUMAN
ID KTBL1_HUMAN Reviewed; 304 AA.
AC Q9H079; A8KAF6; Q2TAC0; Q9H670;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=KATNB1-like protein 1;
DE AltName: Full=Katanin p80 subunit B-like 1 {ECO:0000303|PubMed:26929214};
GN Name=KATNBL1 {ECO:0000303|PubMed:26929214}; Synonyms=C15orf29;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6]
RP FUNCTION, INTERACTION WITH KATNA1 AND KATNAL1, SUBCELLULAR LOCATION, AND
RP MUTAGENESIS OF LYS-9; LYS-10; ARG-11; ARG-26; LYS-27; LYS-28; ARG-71;
RP ARG-72; LYS-73 AND LYS-74.
RX PubMed=26929214; DOI=10.1074/mcp.m115.056465;
RA Cheung K., Senese S., Kuang J., Bui N., Ongpipattanakul C., Gholkar A.,
RA Cohn W., Capri J., Whitelegge J.P., Torres J.Z.;
RT "Proteomic analysis of the mammalian Katanin family of microtubule-severing
RT enzymes defines Katanin p80 subunit B-like 1 (KATNBL1) as a regulator of
RT mammalian Katanin microtubule-severing.";
RL Mol. Cell. Proteomics 15:1658-1669(2016).
CC -!- FUNCTION: Regulates microtubule-severing activity of KATNAL1 in a
CC concentration-dependent manner in vitro. {ECO:0000269|PubMed:26929214}.
CC -!- SUBUNIT: Interacts with KATNA1 and KATNAL1; these interactions are
CC competed by KATNB1 which has a higher affinity for them.
CC {ECO:0000269|PubMed:26929214}.
CC -!- INTERACTION:
CC Q9H079; Q16543: CDC37; NbExp=3; IntAct=EBI-715394, EBI-295634;
CC Q9H079; O95833: CLIC3; NbExp=3; IntAct=EBI-715394, EBI-10192241;
CC Q9H079; Q96FN4: CPNE2; NbExp=5; IntAct=EBI-715394, EBI-7097057;
CC Q9H079; O43559: FRS3; NbExp=3; IntAct=EBI-715394, EBI-725515;
CC Q9H079; P55040: GEM; NbExp=5; IntAct=EBI-715394, EBI-744104;
CC Q9H079; O95872: GPANK1; NbExp=3; IntAct=EBI-715394, EBI-751540;
CC Q9H079; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-715394, EBI-11978177;
CC Q9H079; P13807: GYS1; NbExp=5; IntAct=EBI-715394, EBI-740553;
CC Q9H079; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-715394, EBI-14103818;
CC Q9H079; O75449: KATNA1; NbExp=10; IntAct=EBI-715394, EBI-1048692;
CC Q9H079; Q9BW62: KATNAL1; NbExp=19; IntAct=EBI-715394, EBI-743591;
CC Q9H079; P61968: LMO4; NbExp=3; IntAct=EBI-715394, EBI-2798728;
CC Q9H079; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-715394, EBI-2341787;
CC Q9H079; P55081: MFAP1; NbExp=7; IntAct=EBI-715394, EBI-1048159;
CC Q9H079; Q9HC98-4: NEK6; NbExp=5; IntAct=EBI-715394, EBI-11750983;
CC Q9H079; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-715394, EBI-741158;
CC Q9H079; Q9UBU9: NXF1; NbExp=5; IntAct=EBI-715394, EBI-398874;
CC Q9H079; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-715394, EBI-9057006;
CC Q9H079; P16118: PFKFB1; NbExp=5; IntAct=EBI-715394, EBI-709807;
CC Q9H079; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-715394, EBI-14066006;
CC Q9H079; Q9BUI4: POLR3C; NbExp=3; IntAct=EBI-715394, EBI-5452779;
CC Q9H079; O43741: PRKAB2; NbExp=3; IntAct=EBI-715394, EBI-1053424;
CC Q9H079; P20618: PSMB1; NbExp=5; IntAct=EBI-715394, EBI-372273;
CC Q9H079; O75771: RAD51D; NbExp=3; IntAct=EBI-715394, EBI-1055693;
CC Q9H079; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-715394, EBI-748391;
CC Q9H079; O00560: SDCBP; NbExp=3; IntAct=EBI-715394, EBI-727004;
CC Q9H079; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-715394, EBI-358489;
CC Q9H079; Q92966: SNAPC3; NbExp=3; IntAct=EBI-715394, EBI-1760638;
CC Q9H079; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-715394, EBI-11955057;
CC Q9H079; Q8WV44: TRIM41; NbExp=5; IntAct=EBI-715394, EBI-725997;
CC Q9H079; Q9H6E5: TUT1; NbExp=3; IntAct=EBI-715394, EBI-2511680;
CC Q9H079; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-715394, EBI-14104088;
CC Q9H079; Q86UD4: ZNF329; NbExp=3; IntAct=EBI-715394, EBI-7233259;
CC Q9H079; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-715394, EBI-740727;
CC Q9H079; Q7Z3I7: ZNF572; NbExp=5; IntAct=EBI-715394, EBI-10172590;
CC Q9H079; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-715394, EBI-6427977;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26929214}. Cytoplasm,
CC cytoskeleton, spindle pole {ECO:0000269|PubMed:26929214}.
CC Note=Localizes to the spindle poles only during mitosis. Sequestered to
CC the nucleus during interphase. {ECO:0000269|PubMed:26929214}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15394.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL136908; CAB66842.1; -; mRNA.
DR EMBL; AK026210; BAB15394.1; ALT_INIT; mRNA.
DR EMBL; AK293021; BAF85710.1; -; mRNA.
DR EMBL; CH471125; EAW92288.1; -; Genomic_DNA.
DR EMBL; BC026234; AAH26234.1; -; mRNA.
DR EMBL; BC111000; AAI11001.1; -; mRNA.
DR CCDS; CCDS10034.1; -.
DR RefSeq; NP_078989.1; NM_024713.2.
DR RefSeq; XP_016878060.1; XM_017022571.1.
DR RefSeq; XP_016878061.1; XM_017022572.1.
DR RefSeq; XP_016878062.1; XM_017022573.1.
DR RefSeq; XP_016878063.1; XM_017022574.1.
DR AlphaFoldDB; Q9H079; -.
DR SMR; Q9H079; -.
DR BioGRID; 122873; 47.
DR ComplexPortal; CPX-6366; Katanin complex, KATNA1-KATNBL1 variant.
DR ComplexPortal; CPX-6381; Katanin complex, KATNAL1-KATNBL1 variant.
DR ComplexPortal; CPX-6383; Katanin complex, KATNAL2-KATNBL1 variant.
DR CORUM; Q9H079; -.
DR IntAct; Q9H079; 57.
DR MINT; Q9H079; -.
DR STRING; 9606.ENSP00000256544; -.
DR iPTMnet; Q9H079; -.
DR PhosphoSitePlus; Q9H079; -.
DR BioMuta; KATNBL1; -.
DR DMDM; 73917822; -.
DR EPD; Q9H079; -.
DR jPOST; Q9H079; -.
DR MassIVE; Q9H079; -.
DR MaxQB; Q9H079; -.
DR PaxDb; Q9H079; -.
DR PeptideAtlas; Q9H079; -.
DR PRIDE; Q9H079; -.
DR ProteomicsDB; 80214; -.
DR Antibodypedia; 22695; 84 antibodies from 20 providers.
DR DNASU; 79768; -.
DR Ensembl; ENST00000256544.8; ENSP00000256544.3; ENSG00000134152.11.
DR GeneID; 79768; -.
DR KEGG; hsa:79768; -.
DR MANE-Select; ENST00000256544.8; ENSP00000256544.3; NM_024713.3; NP_078989.1.
DR UCSC; uc001zhp.4; human.
DR CTD; 79768; -.
DR GeneCards; KATNBL1; -.
DR HGNC; HGNC:26199; KATNBL1.
DR HPA; ENSG00000134152; Low tissue specificity.
DR MIM; 616235; gene.
DR neXtProt; NX_Q9H079; -.
DR OpenTargets; ENSG00000134152; -.
DR PharmGKB; PA134985944; -.
DR VEuPathDB; HostDB:ENSG00000134152; -.
DR eggNOG; ENOG502QT0F; Eukaryota.
DR GeneTree; ENSGT00390000012351; -.
DR HOGENOM; CLU_079657_0_0_1; -.
DR InParanoid; Q9H079; -.
DR OMA; TVGLHWV; -.
DR OrthoDB; 1242980at2759; -.
DR PhylomeDB; Q9H079; -.
DR TreeFam; TF332359; -.
DR PathwayCommons; Q9H079; -.
DR SignaLink; Q9H079; -.
DR BioGRID-ORCS; 79768; 11 hits in 1008 CRISPR screens.
DR ChiTaRS; KATNBL1; human.
DR GeneWiki; C15orf29; -.
DR GenomeRNAi; 79768; -.
DR Pharos; Q9H079; Tdark.
DR PRO; PR:Q9H079; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9H079; protein.
DR Bgee; ENSG00000134152; Expressed in lower esophagus mucosa and 190 other tissues.
DR ExpressionAtlas; Q9H079; baseline and differential.
DR Genevisible; Q9H079; HS.
DR GO; GO:0032154; C:cleavage furrow; IDA:HPA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008352; C:katanin complex; IPI:ComplexPortal.
DR GO; GO:0015630; C:microtubule cytoskeleton; IC:ComplexPortal.
DR GO; GO:0030496; C:midbody; IDA:HPA.
DR GO; GO:0072686; C:mitotic spindle; IDA:HPA.
DR GO; GO:0097431; C:mitotic spindle pole; IDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IDA:LIFEdb.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IDA:ComplexPortal.
DR GO; GO:0051495; P:positive regulation of cytoskeleton organization; IDA:UniProtKB.
DR InterPro; IPR028021; Katanin_C-terminal.
DR InterPro; IPR042404; KATNBL1.
DR PANTHER; PTHR14682; PTHR14682; 1.
DR Pfam; PF13925; Katanin_con80; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..304
FT /note="KATNB1-like protein 1"
FT /id="PRO_0000089981"
FT MOTIF 26..33
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 72..79
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOD_RES 61
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MUTAGEN 9
FT /note="K->A: Complete redistribution from the nucleus to
FT the cytoplasm; when associated with A-10; A-11; A-26; A-27;
FT A-28; A-71; A-72; A-73 and A-74."
FT /evidence="ECO:0000269|PubMed:26929214"
FT MUTAGEN 10
FT /note="K->A: Complete redistribution from the nucleus to
FT the cytoplasm; when associated with A-9; A-11; A-26; A-27;
FT A-28; A-71; A-72; A-73 and A-74."
FT /evidence="ECO:0000269|PubMed:26929214"
FT MUTAGEN 11
FT /note="R->A: Complete redistribution from the nucleus to
FT the cytoplasm; when associated with A-9; A-10; A-26; A-27;
FT A-28; A-71; A-72; A-73 and A-74."
FT /evidence="ECO:0000269|PubMed:26929214"
FT MUTAGEN 26
FT /note="R->A: Complete redistribution from the nucleus to
FT the cytoplasm; when associated with A-9; A-10; A-11; A-27;
FT A-28; A-71; A-72; A-73 and A-74."
FT /evidence="ECO:0000269|PubMed:26929214"
FT MUTAGEN 27
FT /note="K->A: Complete redistribution from the nucleus to
FT the cytoplasm; when associated with A-9; A-10; A-11; A-26;
FT A-28; A-71; A-72; A-73 and A-74."
FT /evidence="ECO:0000269|PubMed:26929214"
FT MUTAGEN 28
FT /note="K->A: Complete redistribution from the nucleus to
FT the cytoplasm; when associated with A-9; A-10; A-11; A-26;
FT A-27; A-71; A-72; A-73 and A-74."
FT /evidence="ECO:0000269|PubMed:26929214"
FT MUTAGEN 71
FT /note="R->A: Redistributes from the nucleus to both nucleus
FT and cytoplasm; when associated with A-72; A-73 and A-74.
FT Complete redistribution from the nucleus to the cytoplasm;
FT when associated with A-9; A-10; A-11; A-26; A-27; A-28; A-
FT 72; A-73 and A-74."
FT /evidence="ECO:0000269|PubMed:26929214"
FT MUTAGEN 72
FT /note="R->A: Redistributes from the nucleus to both nucleus
FT and cytoplasm; when associated with A-71; A-73 and A-74.
FT Complete redistribution from the nucleus to the cytoplasm;
FT when associated with A-9; A-10; A-11; A-26; A-27; A-28; A-
FT 71; A-73 and A-74."
FT /evidence="ECO:0000269|PubMed:26929214"
FT MUTAGEN 73
FT /note="K->A: Redistributes from the nucleus to both nucleus
FT and cytoplasm; when associated with A-71; A-72 and A-74.
FT Complete redistribution from the nucleus to the cytoplasm;
FT when associated with A-9; A-10; A-11; A-26; A-27; A-28; A-
FT 71; A-72 and A-74."
FT /evidence="ECO:0000269|PubMed:26929214"
FT MUTAGEN 74
FT /note="K->A: Redistributes from the nucleus to both nucleus
FT and cytoplasm; when associated with A-71; A-72 and A-73.
FT Complete redistribution from the nucleus to the cytoplasm;
FT when associated with A-9; A-10; A-11; A-26; A-27; A-28; A-
FT 71; A-72 and A-73."
FT /evidence="ECO:0000269|PubMed:26929214"
SQ SEQUENCE 304 AA; 34767 MW; 5F7515A3A95FEBBB CRC64;
MASETHNVKK RNFCNKIEDH FIDLPRKKIS NFTNKNMKEV KKSPKQLAAY INRTVGQTVK
SPDKLRKVIY RRKKVHHPFP NPCYRKKQSP GSGGCDMANK ENELACAGHL PEKLHHDSRT
YLVNSSDSGS SQTESPSSKY SGFFSEVSQD HETMAQVLFS RNMRLNVALT FWRKRSISEL
VAYLLRIEDL GVVVDCLPVL TNCLQEEKQY ISLGCCVDLL PLVKSLLKSK FEEYVIVGLN
WLQAVIKRWW SELSSKTEII NDGNIQILKQ QLSGLWEQEN HLTLVPGYTG NIAKDVDAYL
LQLH
