KTBL1_MOUSE
ID KTBL1_MOUSE Reviewed; 299 AA.
AC Q9CWJ3; Q3U7P7; Q8C7R6;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=KATNB1-like protein 1;
DE AltName: Full=Katanin p80 subunit B-like 1;
GN Name=Katnbl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Bone marrow, Embryonic stem cell, Liver, and Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulates microtubule-severing activity of KATNAL1 in a
CC concentration-dependent manner in vitro.
CC {ECO:0000250|UniProtKB:Q9H079}.
CC -!- SUBUNIT: Interacts with KATNA1 and KATNAL1; these interactions are
CC competed by KATNB1 which has a higher affinity for them.
CC {ECO:0000250|UniProtKB:Q9H079}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H079}.
CC Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9H079}.
CC Note=Localizes to the spindle poles only during mitosis. Sequestered to
CC the nucleus during interphase. {ECO:0000250|UniProtKB:Q9H079}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK010654; BAB27094.1; -; mRNA.
DR EMBL; AK036861; BAC29607.1; -; mRNA.
DR EMBL; AK151464; BAE30422.1; -; mRNA.
DR EMBL; AK152570; BAE31322.1; -; mRNA.
DR EMBL; AK168639; BAE40498.1; -; mRNA.
DR EMBL; BC003216; AAH03216.1; -; mRNA.
DR EMBL; BC080661; AAH80661.1; -; mRNA.
DR EMBL; BC012402; AAH12402.1; -; mRNA.
DR CCDS; CCDS16554.1; -.
DR RefSeq; NP_077216.1; NM_024254.3.
DR AlphaFoldDB; Q9CWJ3; -.
DR SMR; Q9CWJ3; -.
DR IntAct; Q9CWJ3; 1.
DR MINT; Q9CWJ3; -.
DR STRING; 10090.ENSMUSP00000028552; -.
DR iPTMnet; Q9CWJ3; -.
DR PhosphoSitePlus; Q9CWJ3; -.
DR EPD; Q9CWJ3; -.
DR MaxQB; Q9CWJ3; -.
DR PaxDb; Q9CWJ3; -.
DR PeptideAtlas; Q9CWJ3; -.
DR PRIDE; Q9CWJ3; -.
DR ProteomicsDB; 263571; -.
DR Antibodypedia; 22695; 84 antibodies from 20 providers.
DR Ensembl; ENSMUST00000028552; ENSMUSP00000028552; ENSMUSG00000027132.
DR GeneID; 72425; -.
DR KEGG; mmu:72425; -.
DR UCSC; uc008lpa.1; mouse.
DR CTD; 79768; -.
DR MGI; MGI:1919675; Katnbl1.
DR VEuPathDB; HostDB:ENSMUSG00000027132; -.
DR eggNOG; ENOG502QT0F; Eukaryota.
DR GeneTree; ENSGT00390000012351; -.
DR HOGENOM; CLU_079657_0_0_1; -.
DR InParanoid; Q9CWJ3; -.
DR OMA; TVGLHWV; -.
DR OrthoDB; 1242980at2759; -.
DR PhylomeDB; Q9CWJ3; -.
DR TreeFam; TF332359; -.
DR BioGRID-ORCS; 72425; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Katnbl1; mouse.
DR PRO; PR:Q9CWJ3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CWJ3; protein.
DR Bgee; ENSMUSG00000027132; Expressed in animal zygote and 231 other tissues.
DR Genevisible; Q9CWJ3; MM.
DR GO; GO:0032154; C:cleavage furrow; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008352; C:katanin complex; ISO:MGI.
DR GO; GO:0030496; C:midbody; ISO:MGI.
DR GO; GO:0072686; C:mitotic spindle; ISO:MGI.
DR GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; ISO:MGI.
DR GO; GO:0051495; P:positive regulation of cytoskeleton organization; ISS:UniProtKB.
DR InterPro; IPR028021; Katanin_C-terminal.
DR InterPro; IPR042404; KATNBL1.
DR PANTHER; PTHR14682; PTHR14682; 1.
DR Pfam; PF13925; Katanin_con80; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..299
FT /note="KATNB1-like protein 1"
FT /id="PRO_0000089982"
FT MOTIF 8..15
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOD_RES 56
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H079"
SQ SEQUENCE 299 AA; 34035 MW; 9799B6ABB99FF6EE CRC64;
MAFDTHHVKK RNFSNSIDLP RKRISNFTSK NMKEVKRSPK QLAAYISRTV AQAVKSPEKL
RKVLYHRKLV RRSFPNPCYK TKQSPKSGGC DMANKENELA CAGHLPENLR HDSRTFVINT
SDSGSSQTES PSSKYSGFFS EVSQDHETMA QVLFSRNLRL NVALTFWRKR SISELVAYLV
RIEDLGVVVD CLPVLTNSLQ EEKQYISLGC CVDLLPLVKS LLQSRFEEYV IVGLNWLQAV
IKRWWSELSS TSEIISDGNI KILKQQLSGL WEQESHLTLV PGYTGNIAKD VDAYLLQLH
