ID   KTDAP_CANLF             Reviewed;          99 AA.
AC   Q52MQ7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Keratinocyte differentiation-associated protein;
DE   Flags: Precursor;
GN   Name=KRTDAP {ECO:0000250|UniProtKB:P60985};
GN   Synonyms=KDAP {ECO:0000303|PubMed:15927493};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAY14575.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=15927493; DOI=10.1016/j.tvjl.2005.04.009;
RA   Yagihara H., Terada Y., Sugimoto S., Hidaka F., Yamada O., Ono K.,
RA   Washizu T., Ariizumi K., Bonkobara M.;
RT   "Identification and cornification-related gene expression of canine
RT   keratinocyte differentiation-associated protein, Kdap.";
RL   Vet. J. 172:141-146(2006).
CC   -!- FUNCTION: May act as a soluble regulator of keratinocyte
CC       differentiation. May play an important role in embryonic skin
CC       morphogenesis (By similarity). {ECO:0000250|UniProtKB:P60985,
CC       ECO:0000250|UniProtKB:P85411}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60985}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in skin, but not detectable in any
CC       other tissue examined. Expression restricted to cornified/stratified
CC       epithelia and not detected in non-cornified/stratified epithelia.
CC       {ECO:0000269|PubMed:15927493}.
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DR   EMBL; AY999063; AAY14575.1; -; mRNA.
DR   RefSeq; NP_001019813.1; NM_001024642.1.
DR   AlphaFoldDB; Q52MQ7; -.
DR   STRING; 9615.ENSCAFP00000010433; -.
DR   PaxDb; Q52MQ7; -.
DR   GeneID; 554216; -.
DR   KEGG; cfa:554216; -.
DR   CTD; 388533; -.
DR   eggNOG; ENOG502STEA; Eukaryota.
DR   InParanoid; Q52MQ7; -.
DR   OrthoDB; 1591084at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   InterPro; IPR028196; KRTDAP.
DR   PANTHER; PTHR36463; PTHR36463; 1.
DR   Pfam; PF15200; KRTDAP; 1.
PE   2: Evidence at transcript level;
KW   Differentiation; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..99
FT                   /note="Keratinocyte differentiation-associated protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000317055"
SQ   SEQUENCE   99 AA;  10848 MW;  D5390C10DB0EA48E CRC64;
     MKIPVLPAVV LLSLLALHSA QGASLGSSEE ETTIGNYAAG PEAFNAQFLN IDKLRSAFKP
     DEFLNWHALF ESIKRKLPFL NWDALPKLKG LRSATPDAQ