KTDAP_HUMAN
ID KTDAP_HUMAN Reviewed; 99 AA.
AC P60985; A1L4D7;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Keratinocyte differentiation-associated protein;
DE Flags: Precursor;
GN Name=KRTDAP; Synonyms=KDAP; ORFNames=UNQ467/PRO826;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, INDUCTION, AND ALTERNATIVE SPLICING.
RX PubMed=15140226; DOI=10.1111/j.0022-202x.2004.22511.x;
RA Tsuchida S., Bonkobara M., McMillan J.R., Akiyama M., Yudate T.,
RA Aragane Y., Tezuka T., Shimizu H., Cruz P.D. Jr., Ariizumi K.;
RT "Characterization of Kdap, a protein secreted by keratinocytes.";
RL J. Invest. Dermatol. 122:1225-1234(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a soluble regulator of keratinocyte
CC differentiation. May play an important role in embryonic skin
CC morphogenesis. {ECO:0000269|PubMed:15140226}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15140226}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P60985-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P60985-2; Sequence=VSP_030856;
CC -!- TISSUE SPECIFICITY: Highly expressed in skin and detected at lower
CC levels in thymus. In skin, found exclusively in lamellar granules of
CC granular keratinocytes and in the intracellular space of the stratum
CC corneum. Also highly expressed in oral mucosa, tongue, esophagus, and
CC stomach, and at much lower levels in bladder and uterus. Not detected
CC in gastrointestinal mucosa. {ECO:0000269|PubMed:15140226}.
CC -!- INDUCTION: Up-regulated in situ in psoriatic skin (at protein level).
CC {ECO:0000269|PubMed:15140226}.
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DR EMBL; AY359007; AAQ89366.1; -; mRNA.
DR EMBL; BC130501; AAI30502.1; -; mRNA.
DR CCDS; CCDS12462.1; -. [P60985-1]
DR CCDS; CCDS59377.1; -. [P60985-2]
DR RefSeq; NP_001231776.1; NM_001244847.1. [P60985-2]
DR RefSeq; NP_997275.1; NM_207392.2. [P60985-1]
DR AlphaFoldDB; P60985; -.
DR SMR; P60985; -.
DR STRING; 9606.ENSP00000339251; -.
DR GlyGen; P60985; 2 sites, 2 O-linked glycans (2 sites).
DR iPTMnet; P60985; -.
DR PhosphoSitePlus; P60985; -.
DR BioMuta; KRTDAP; -.
DR MassIVE; P60985; -.
DR PaxDb; P60985; -.
DR PeptideAtlas; P60985; -.
DR PRIDE; P60985; -.
DR ProteomicsDB; 57243; -. [P60985-1]
DR ProteomicsDB; 57244; -. [P60985-2]
DR Antibodypedia; 74487; 4 antibodies from 4 providers.
DR DNASU; 388533; -.
DR Ensembl; ENST00000338897.4; ENSP00000339251.3; ENSG00000188508.11. [P60985-1]
DR Ensembl; ENST00000484218.6; ENSP00000470713.1; ENSG00000188508.11. [P60985-2]
DR GeneID; 388533; -.
DR KEGG; hsa:388533; -.
DR MANE-Select; ENST00000338897.4; ENSP00000339251.3; NM_207392.3; NP_997275.1.
DR UCSC; uc002nzh.4; human. [P60985-1]
DR CTD; 388533; -.
DR DisGeNET; 388533; -.
DR GeneCards; KRTDAP; -.
DR HGNC; HGNC:16313; KRTDAP.
DR HPA; ENSG00000188508; Group enriched (skin, vagina).
DR neXtProt; NX_P60985; -.
DR OpenTargets; ENSG00000188508; -.
DR PharmGKB; PA30236; -.
DR VEuPathDB; HostDB:ENSG00000188508; -.
DR eggNOG; ENOG502STEA; Eukaryota.
DR GeneTree; ENSGT00390000009097; -.
DR HOGENOM; CLU_183149_0_0_1; -.
DR InParanoid; P60985; -.
DR OMA; FNANFLN; -.
DR OrthoDB; 1591084at2759; -.
DR PhylomeDB; P60985; -.
DR TreeFam; TF341267; -.
DR PathwayCommons; P60985; -.
DR BioGRID-ORCS; 388533; 22 hits in 1059 CRISPR screens.
DR ChiTaRS; KRTDAP; human.
DR GeneWiki; KRTDAP; -.
DR GenomeRNAi; 388533; -.
DR Pharos; P60985; Tdark.
DR PRO; PR:P60985; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P60985; protein.
DR Bgee; ENSG00000188508; Expressed in penis and 104 other tissues.
DR Genevisible; P60985; HS.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0042599; C:lamellar body; IDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; IBA:GO_Central.
DR InterPro; IPR028196; KRTDAP.
DR PANTHER; PTHR36463; PTHR36463; 1.
DR Pfam; PF15200; KRTDAP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Differentiation; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..99
FT /note="Keratinocyte differentiation-associated protein"
FT /id="PRO_0000022609"
FT VAR_SEQ 45..58
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15140226"
FT /id="VSP_030856"
SQ SEQUENCE 99 AA; 11050 MW; 0F966EC142C89838 CRC64;
MKIPVLPAVV LLSLLVLHSA QGATLGGPEE ESTIENYASR PEAFNTPFLN IDKLRSAFKA
DEFLNWHALF ESIKRKLPFL NWDAFPKLKG LRSATPDAQ
