KTDAP_MOUSE
ID KTDAP_MOUSE Reviewed; 102 AA.
AC Q3V2T4; B7ZNU7; Q3V2T1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Keratinocyte differentiation-associated protein;
DE Flags: Precursor;
GN Name=Krtdap {ECO:0000312|MGI:MGI:1928282};
GN Synonyms=Kdap {ECO:0000303|PubMed:15256262};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=15256262; DOI=10.1016/j.gene.2004.03.010;
RA Moffatt P., Salois P., St Amant N., Gaumond M.-H., Lanctot C.;
RT "Identification of a conserved cluster of skin-specific genes encoding
RT secreted proteins.";
RL Gene 334:123-131(2004).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAE20713.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE20713.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAE20713.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAI32511.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryo {ECO:0000312|EMBL:AAI32511.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a soluble regulator of keratinocyte
CC differentiation. May play an important role in embryonic skin
CC morphogenesis (By similarity). {ECO:0000250|UniProtKB:P60985,
CC ECO:0000250|UniProtKB:P85411}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15256262}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:15256262, ECO:0000269|PubMed:15489334,
CC ECO:0000269|PubMed:16141072};
CC IsoId=Q3V2T4-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:16141072};
CC IsoId=Q3V2T4-2; Sequence=VSP_052660;
CC -!- TISSUE SPECIFICITY: Expression restricted to suprabasal keratinocytes
CC of the epidermis. {ECO:0000269|PubMed:15256262}.
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DR EMBL; AK131603; BAE20713.1; -; mRNA.
DR EMBL; AK131606; BAE20716.1; -; mRNA.
DR EMBL; BC132510; AAI32511.1; -; mRNA.
DR EMBL; BC132512; AAI32513.1; -; mRNA.
DR EMBL; BC145438; AAI45439.1; -; mRNA.
DR CCDS; CCDS21110.1; -. [Q3V2T4-1]
DR CCDS; CCDS90204.1; -. [Q3V2T4-2]
DR RefSeq; NP_001028303.1; NM_001033131.3. [Q3V2T4-1]
DR AlphaFoldDB; Q3V2T4; -.
DR STRING; 10090.ENSMUSP00000096159; -.
DR iPTMnet; Q3V2T4; -.
DR PhosphoSitePlus; Q3V2T4; -.
DR MaxQB; Q3V2T4; -.
DR PaxDb; Q3V2T4; -.
DR PeptideAtlas; Q3V2T4; -.
DR PRIDE; Q3V2T4; -.
DR ProteomicsDB; 264801; -. [Q3V2T4-1]
DR ProteomicsDB; 264802; -. [Q3V2T4-2]
DR Antibodypedia; 74487; 4 antibodies from 4 providers.
DR Ensembl; ENSMUST00000098559; ENSMUSP00000096159; ENSMUSG00000074199. [Q3V2T4-1]
DR Ensembl; ENSMUST00000190990; ENSMUSP00000139461; ENSMUSG00000074199. [Q3V2T4-2]
DR GeneID; 64661; -.
DR KEGG; mmu:64661; -.
DR UCSC; uc009ggl.1; mouse. [Q3V2T4-2]
DR UCSC; uc009ggm.1; mouse. [Q3V2T4-1]
DR CTD; 388533; -.
DR MGI; MGI:1928282; Krtdap.
DR VEuPathDB; HostDB:ENSMUSG00000074199; -.
DR eggNOG; ENOG502STEA; Eukaryota.
DR GeneTree; ENSGT00390000009097; -.
DR InParanoid; Q3V2T4; -.
DR OMA; FNANFLN; -.
DR OrthoDB; 1591084at2759; -.
DR PhylomeDB; Q3V2T4; -.
DR TreeFam; TF341267; -.
DR BioGRID-ORCS; 64661; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Krtdap; mouse.
DR PRO; PR:Q3V2T4; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3V2T4; protein.
DR Bgee; ENSMUSG00000074199; Expressed in tail skin and 84 other tissues.
DR ExpressionAtlas; Q3V2T4; baseline and differential.
DR Genevisible; Q3V2T4; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0042599; C:lamellar body; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; ISO:MGI.
DR InterPro; IPR028196; KRTDAP.
DR PANTHER; PTHR36463; PTHR36463; 1.
DR Pfam; PF15200; KRTDAP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Differentiation; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..102
FT /note="Keratinocyte differentiation-associated protein"
FT /evidence="ECO:0000255"
FT /id="PRO_0000317056"
FT VAR_SEQ 91..102
FT /note="VKGLRSAAPDSQ -> T (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_052660"
FT CONFLICT 2
FT /note="K -> R (in Ref. 2; BAE20716)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 102 AA; 11497 MW; 5EDF30256BA0CD79 CRC64;
MKIPILPVVA LLSLLALHAV QGAALGHPTI YPEDSSYNNY PTATEGLNNE FLNFKRLQSA
FQSENFLNWH VITDMFKNAF PFINWDFFPK VKGLRSAAPD SQ
