ID   KTDAP_RAT               Reviewed;          98 AA.
AC   P85411;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Keratinocyte differentiation-associated protein;
DE   Flags: Precursor;
GN   Name=Krtdap {ECO:0000312|RGD:71086};
GN   Synonyms=Kdap {ECO:0000303|PubMed:11054531};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, TISSUE
RP   SPECIFICITY, AND INDUCTION.
RX   PubMed=11054531; DOI=10.1016/s0378-1119(00)00357-7;
RA   Oomizu S., Sahuc F., Asahina K., Inamatsu M., Matsuzaki T., Sasaki M.,
RA   Obara M., Yoshizato K.;
RT   "Kdap, a novel gene associated with the stratification of the epithelium.";
RL   Gene 256:19-27(2000).
CC   -!- FUNCTION: May act as a soluble regulator of keratinocyte
CC       differentiation (By similarity). May play an important role in
CC       embryonic skin morphogenesis. {ECO:0000250|UniProtKB:P60985,
CC       ECO:0000269|PubMed:11054531}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60985}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1 {ECO:0000269|PubMed:11054531}; Synonyms=a
CC       {ECO:0000269|PubMed:11054531};
CC         IsoId=P85411-1; Sequence=Displayed;
CC       Name=2 {ECO:0000269|PubMed:11054531}; Synonyms=b
CC       {ECO:0000269|PubMed:11054531};
CC         IsoId=P85411-2; Sequence=VSP_030857;
CC       Name=3 {ECO:0000269|PubMed:11054531}; Synonyms=c
CC       {ECO:0000269|PubMed:11054531};
CC         IsoId=P85411-3; Sequence=VSP_030858;
CC       Name=4 {ECO:0000269|PubMed:11054531}; Synonyms=d
CC       {ECO:0000269|PubMed:11054531};
CC         IsoId=P85411-4; Sequence=VSP_030857, VSP_030858;
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed in stratified epithelium.
CC       {ECO:0000269|PubMed:11054531}.
CC   -!- INDUCTION: Up-regulated in suprabasal cell layers of embryonic and
CC       adult epidermis. {ECO:0000269|PubMed:11054531}.
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DR   EMBL; AB011028; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P85411; -.
DR   RGD; 71086; Krtdap.
DR   InParanoid; P85411; -.
DR   PhylomeDB; P85411; -.
DR   PRO; PR:P85411; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0042599; C:lamellar body; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008544; P:epidermis development; IDA:RGD.
DR   InterPro; IPR028196; KRTDAP.
DR   PANTHER; PTHR36463; PTHR36463; 1.
DR   Pfam; PF15200; KRTDAP; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Differentiation; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..98
FT                   /note="Keratinocyte differentiation-associated protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000317057"
FT   VAR_SEQ         43..55
FT                   /note="Missing (in isoform 2 and isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:11054531"
FT                   /id="VSP_030857"
FT   VAR_SEQ         87..98
FT                   /note="Missing (in isoform 3 and isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:11054531"
FT                   /id="VSP_030858"
SQ   SEQUENCE   98 AA;  10827 MW;  67E1D1AA60034F86 CRC64;
     MKIPILPIVA LLSLLALHAA QGAALGTPME DTTSSNYPSG TEGLSEFLNF NKLQSAFKSD
     DFLNWHVLTD MFKKALPFIN WEFFPKVKGL RSAVPDSQ