KTHY2_SACS2
ID KTHY2_SACS2 Reviewed; 213 AA.
AC P58157;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Probable thymidylate kinase 2;
DE EC=2.7.4.9;
DE AltName: Full=dTMP kinase 2;
GN Name=tmk2; OrderedLocusNames=SSO1192; ORFNames=C50_002;
OS Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS (Sulfolobus solfataricus).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Saccharolobus.
OX NCBI_TaxID=273057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC ChEBI:CHEBI:456216; EC=2.7.4.9;
CC -!- SIMILARITY: Belongs to the thymidylate kinase family. {ECO:0000305}.
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DR EMBL; AE006641; AAK41441.1; -; Genomic_DNA.
DR PIR; B90273; B90273.
DR RefSeq; WP_009992803.1; NC_002754.1.
DR AlphaFoldDB; P58157; -.
DR SMR; P58157; -.
DR STRING; 273057.SSO1192; -.
DR EnsemblBacteria; AAK41441; AAK41441; SSO1192.
DR GeneID; 44130125; -.
DR KEGG; sso:SSO1192; -.
DR PATRIC; fig|273057.12.peg.1192; -.
DR eggNOG; arCOG01891; Archaea.
DR HOGENOM; CLU_049131_1_3_2; -.
DR InParanoid; P58157; -.
DR OMA; WIHEVIK; -.
DR PhylomeDB; P58157; -.
DR Proteomes; UP000001974; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004798; F:thymidylate kinase activity; IBA:GO_Central.
DR GO; GO:0009041; F:uridylate kinase activity; IBA:GO_Central.
DR GO; GO:0006233; P:dTDP biosynthetic process; IBA:GO_Central.
DR GO; GO:0006235; P:dTTP biosynthetic process; IBA:GO_Central.
DR GO; GO:0006227; P:dUDP biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018094; Thymidylate_kinase.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide biosynthesis; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..213
FT /note="Probable thymidylate kinase 2"
FT /id="PRO_0000155399"
FT BINDING 10..17
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 213 AA; 25001 MW; 3A5BCCFD2F067A7D CRC64;
MRGLLIAFEG IDGSGKSSQA VLLKDWIEMR RDVYLTEWNS SEWIHDIIKE AKKKNMLTSI
TFSLIHATDF SDRYERYILP MLKSGFVVIC DRYVYTAYAR DVVRNVDFDW VKRLYSFAIK
PNFTFYIRVT PEIALERIRK AKRKIKPQEA GIDILGEIPL EEGFLKYQSR IVEIYDKIAK
EESNFITIDG NRPLKDVQID IRKILGEYID NSL