ID   KTHY_ABVP               Reviewed;         156 AA.
AC   A4ZU96;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Putative thymidylate kinase;
DE            EC=2.7.4.9;
DE   AltName: Full=dTMP kinase;
GN   ORFNames=ORF156;
OS   Acidianus bottle-shaped virus (isolate Italy/Pozzuoli) (ABV).
OC   Viruses; Ampullaviridae; Bottigliavirus; Bottigliavirus ABV.
OX   NCBI_TaxID=654911;
OH   NCBI_TaxID=269667; Acidianus convivator.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17412384; DOI=10.1016/j.virol.2007.03.005;
RA   Peng X., Basta T., Haring M., Garrett R.A., Prangishvili D.;
RT   "Genome of the Acidianus bottle-shaped virus and insights into the
RT   replication and packaging mechanisms.";
RL   Virology 364:237-243(2007).
CC   -!- FUNCTION: Catalyzes the conversion of dTMP to dTDP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9;
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family. {ECO:0000305}.
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DR   EMBL; EF432053; ABP73400.1; -; Genomic_DNA.
DR   RefSeq; YP_001210314.1; NC_009452.1.
DR   SMR; A4ZU96; -.
DR   GeneID; 5129814; -.
DR   KEGG; vg:5129814; -.
DR   UniPathway; UPA00575; -.
DR   Proteomes; UP000000513; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR007936; VirE.
DR   Pfam; PF05272; VirE; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide biosynthesis; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..156
FT                   /note="Putative thymidylate kinase"
FT                   /id="PRO_0000384819"
FT   BINDING         7..14
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   156 AA;  18306 MW;  A980DA08A906E674 CRC64;
     MIYILEGLDG TGKTSFASEL IKSQVFSRPM YVYFSKEDSY ENTKLAWVSL IKELSKLNFN
     IIMDRSIIST IAYHFTYRPS KEYENFIRSE LESVLNLDPS KAVFIHFVKV HDSKKLLEYA
     NRVKSIRDNY HLLMRILREK GFNVIVNGGQ KDFNLF