ID   ARCA_BACLD              Reviewed;         413 AA.
AC   O86131; Q62NR4; Q65D88;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Arginine deiminase;
DE            Short=ADI;
DE            EC=3.5.3.6;
DE   AltName: Full=Arginine dihydrolase;
DE            Short=AD;
GN   Name=arcA; OrderedLocusNames=BLi04163, BL01912;
OS   Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS   NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=279010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9851988; DOI=10.1128/jb.180.24.6468-6475.1998;
RA   Maghnouj A., de Sousa Cabral T.F., Stalon V., Vander Wauven C.;
RT   "The arcABDC gene cluster, encoding the arginine deiminase pathway of
RT   Bacillus licheniformis, and its activation by the arginine repressor
RT   argR.";
RL   J. Bacteriol. 180:6468-6475(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15383718; DOI=10.1159/000079829;
RA   Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA   Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT   "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT   with great industrial potential.";
RL   J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA   Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA   Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA   Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA   Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT   "Complete genome sequence of the industrial bacterium Bacillus
RT   licheniformis and comparisons with closely related Bacillus species.";
RL   Genome Biol. 5:R77.1-R77.12(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAU25597.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Y17554; CAA76777.1; -; Genomic_DNA.
DR   EMBL; AE017333; AAU42976.1; -; Genomic_DNA.
DR   EMBL; CP000002; AAU25597.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; O86131; -.
DR   SMR; O86131; -.
DR   STRING; 279010.BL01912; -.
DR   PRIDE; O86131; -.
DR   EnsemblBacteria; AAU25597; AAU25597; BL01912.
DR   KEGG; bld:BLi04163; -.
DR   KEGG; bli:BL01912; -.
DR   eggNOG; COG2235; Bacteria.
DR   HOGENOM; CLU_052662_0_1_9; -.
DR   OMA; ERATMHL; -.
DR   BioCyc; BLIC279010:BLI_RS20475-MON; -.
DR   UniPathway; UPA00254; UER00364.
DR   Proteomes; UP000000606; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..413
FT                   /note="Arginine deiminase"
FT                   /id="PRO_0000182201"
FT   ACT_SITE        402
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   413 AA;  47427 MW;  57BB97714CAA5480 CRC64;
     MIMTTPIHVY SEIGPLKTVM LKRPGRELEN LTPEYLERLL FDDIPFLPAV QKEHDQFAET
     LKQQGAEVLY LEKLTAEALD DALVREQFID ELLTESKADI NGAYDRLKEF LLTFDADSMV
     EQVMSGIRKN ELEREKKSHL HELMEDHYPF YLDPMPNLYF TRDPAAAIGS GLTINKMKEP
     ARRRESLFMR YIINHHPRFK GHEIPVWLDR DFKFNIEGGD ELVLNEETVA IGVSERTTAQ
     AIERLVRNLF QRQSRIRRVL AVEIPKSRAF MHLDTVFTMV DRDQFTIHPA IQGPEGDMRI
     FVLERGKTAD EIHTTEEHNL PEVLKRTLGL SDVNLIFCGG GDEIASAREQ WNDGSNTLAI
     APGVVVTYDR NYISNECLRE QGIKVIEIPS GELSRGRGGP RCMSMPLYRE DVK