ID   KTHY_ASFB7              Reviewed;         240 AA.
AC   P42490;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Thymidylate kinase;
DE            EC=2.7.4.9;
DE   AltName: Full=dTMP kinase;
GN   Name=TMK; OrderedLocusNames=BA71V-034; ORFNames=A240L;
OS   African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10498;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8393914; DOI=10.1099/0022-1317-74-8-1633;
RA   Yanez R.J., Rodriguez J.M., Rodriguez J.F., Salas M.L., Vinuela E.;
RT   "African swine fever virus thymidylate kinase gene: sequence and
RT   transcriptional mapping.";
RL   J. Gen. Virol. 74:1633-1638(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11831707; DOI=10.1006/viro.1995.1149;
RA   Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C.,
RA   Rodriguez J.F., Vinuela E.;
RT   "Analysis of the complete nucleotide sequence of African swine fever
RT   virus.";
RL   Virology 208:249-278(1995).
CC   -!- FUNCTION: Catalyzes the conversion of dTMP to dTDP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9;
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family. {ECO:0000305}.
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DR   EMBL; Z19544; CAA79604.1; -; Genomic_DNA.
DR   EMBL; U18466; AAA65265.1; -; Genomic_DNA.
DR   PIR; JQ2161; JQ2161.
DR   RefSeq; NP_042729.1; NC_001659.2.
DR   SMR; P42490; -.
DR   PRIDE; P42490; -.
DR   GeneID; 22220417; -.
DR   KEGG; vg:22220417; -.
DR   UniPathway; UPA00575; -.
DR   Proteomes; UP000000624; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide biosynthesis; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..240
FT                   /note="Thymidylate kinase"
FT                   /id="PRO_0000155215"
FT   BINDING         10..17
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   240 AA;  27755 MW;  AF89DBE6CCE3E44D CRC64;
     MRGILITIEG INGVGKSTQA MRLKKALECM DYNAVCIRFP NPDTTTGGLI LQVLNKMTEM
     SSEQLHKLFT KHHSEFSAEI AALLKLNFIV IVDHYIWSGL AYAQADGITI ETKNIFKPDY
     TFFLSSKKPL NEKPLTLQRL FETKEKQETI FTNFTIIMND VPKNRLCIIP ATLNKEIIHT
     MILTKTIKVF DNNSCLNYIK MYDDKYLNVQ DLNLFDFDWQ KCIEDNNDKE EYDDDDGFII