ID   ARCA_BRADU              Reviewed;         420 AA.
AC   Q89DX7;
DT   03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Arginine deiminase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=ADI {ECO:0000255|HAMAP-Rule:MF_00242};
DE            EC=3.5.3.6 {ECO:0000255|HAMAP-Rule:MF_00242};
DE   AltName: Full=Arginine dihydrolase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=AD {ECO:0000255|HAMAP-Rule:MF_00242};
GN   Name=arcA {ECO:0000255|HAMAP-Rule:MF_00242}; OrderedLocusNames=bll7310;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00242};
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
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DR   EMBL; BA000040; BAC52575.1; -; Genomic_DNA.
DR   RefSeq; NP_773950.1; NC_004463.1.
DR   RefSeq; WP_011090045.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q89DX7; -.
DR   SMR; Q89DX7; -.
DR   STRING; 224911.27355592; -.
DR   EnsemblBacteria; BAC52575; BAC52575; BAC52575.
DR   GeneID; 64027064; -.
DR   KEGG; bja:bll7310; -.
DR   PATRIC; fig|224911.44.peg.7386; -.
DR   eggNOG; COG2235; Bacteria.
DR   HOGENOM; CLU_052662_0_0_5; -.
DR   InParanoid; Q89DX7; -.
DR   OMA; SAWIYDG; -.
DR   PhylomeDB; Q89DX7; -.
DR   UniPathway; UPA00254; UER00364.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IBA:GO_Central.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019546; P:arginine deiminase pathway; IBA:GO_Central.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..420
FT                   /note="Arginine deiminase"
FT                   /id="PRO_0000182205"
FT   ACT_SITE        408
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00242"
SQ   SEQUENCE   420 AA;  46410 MW;  5B291544579C5AA9 CRC64;
     MAKQASESNR AFGVHSEVGQ LRKVMVCSPG RAHQRLTPSN CDTLLFDDVL WVENAKRDHF
     DFVQKMRDRG VDVVEMHNLL TETVAIPEGR KWILDNQVVP DQVGLGLVDE LRGYLESLTP
     RDLAETLIGG VSTHDFPDAH GGEMLKLVRE AAGMTEYLLP PLPNTLYTRD TTCWIYGGVT
     LNSLYWPARH EEPILATAIY KFHPDFAGKV NVWWGDPTRD HGLATLEGGD VMPIGKGNVL
     IGLSERTSRQ AISQVAAALF KKKAAERVIV AAMPKLRAAM HLDTVFTFAD RDCVLLYPDI
     VNNIAAFSYR PADNSAGLEL RKDEKPFVDV VAEALGLKKL RVVETGGNAY MRERTQWDSG
     ANLVCASPGV VFAYDRNTYT NTLLRKEGIE VITIVGAELG RGRGGGHCMT CPITRDAVDY