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KTHY_CAEEL
ID   KTHY_CAEEL              Reviewed;         218 AA.
AC   Q22018;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Thymidylate kinase {ECO:0000250|UniProtKB:P23919};
DE            EC=2.7.4.9;
DE   AltName: Full=dTMP kinase;
GN   Name=dtmk-1 {ECO:0000312|WormBase:R53.2};
GN   ORFNames=R53.2 {ECO:0000312|WormBase:R53.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Catalyzes the conversion of dTMP to dTDP. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9;
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family. {ECO:0000305}.
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DR   EMBL; Z66515; CAA91347.1; -; Genomic_DNA.
DR   PIR; T24244; T24244.
DR   RefSeq; NP_496151.1; NM_063750.3.
DR   AlphaFoldDB; Q22018; -.
DR   SMR; Q22018; -.
DR   BioGRID; 39873; 9.
DR   STRING; 6239.R53.2; -.
DR   EPD; Q22018; -.
DR   PaxDb; Q22018; -.
DR   PeptideAtlas; Q22018; -.
DR   EnsemblMetazoa; R53.2.1; R53.2.1; WBGene00011272.
DR   GeneID; 174553; -.
DR   KEGG; cel:CELE_R53.2; -.
DR   UCSC; R53.2; c. elegans.
DR   CTD; 174553; -.
DR   WormBase; R53.2; CE03571; WBGene00011272; dtmk-1.
DR   eggNOG; KOG3327; Eukaryota.
DR   GeneTree; ENSGT00940000154030; -.
DR   HOGENOM; CLU_049131_3_1_1; -.
DR   InParanoid; Q22018; -.
DR   OMA; CYAPERG; -.
DR   OrthoDB; 1259751at2759; -.
DR   PhylomeDB; Q22018; -.
DR   UniPathway; UPA00575; -.
DR   PRO; PR:Q22018; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00011272; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004550; F:nucleoside diphosphate kinase activity; IBA:GO_Central.
DR   GO; GO:0004798; F:thymidylate kinase activity; IBA:GO_Central.
DR   GO; GO:0009041; F:uridylate kinase activity; IBA:GO_Central.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006227; P:dUDP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide biosynthesis; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..218
FT                   /note="Thymidylate kinase"
FT                   /id="PRO_0000155212"
FT   BINDING         15..22
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   218 AA;  24342 MW;  28CBE4E8C8A38192 CRC64;
     MATDQKRGLL IVFEGLDRSG KSTQAKRLVE SINKKSTESG DASSSPSAVL QAFPDRSSSI
     GKLIDQYLRK EIDMDEHALH LLFSADRFSK NQMIRDNIAK GIDVICDRYC YSGVAYSLAK
     GLPEQWVRSS DVGLPKPDAV LFFDVSPEVA AQRGGFGEER LETATIQQKV AAVMPTLRDD
     AYWKTVNADG DLDSVEKNVF RIYENLDREK PFESLEKI
 
 
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