ARCA_CORA7
ID ARCA_CORA7 Reviewed; 415 AA.
AC C3PEE7;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Arginine deiminase {ECO:0000255|HAMAP-Rule:MF_00242};
DE Short=ADI {ECO:0000255|HAMAP-Rule:MF_00242};
DE EC=3.5.3.6 {ECO:0000255|HAMAP-Rule:MF_00242};
DE AltName: Full=Arginine dihydrolase {ECO:0000255|HAMAP-Rule:MF_00242};
DE Short=AD {ECO:0000255|HAMAP-Rule:MF_00242};
GN Name=arcA {ECO:0000255|HAMAP-Rule:MF_00242}; OrderedLocusNames=cauri_0604;
OS Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CIP 107346 /
OS CN-1) (Corynebacterium nigricans).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=548476;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700975 / DSM 44827 / CIP 107346 / CN-1;
RX PubMed=20137072; DOI=10.1186/1471-2164-11-91;
RA Trost E., Gotker S., Schneider J., Schneiker-Bekel S., Szczepanowski R.,
RA Tilker A., Viehoever P., Arnold W., Bekel T., Blom J., Gartemann K.H.,
RA Linke B., Goesmann A., Puhler A., Shukla S.K., Tauch A.;
RT "Complete genome sequence and lifestyle of black-pigmented Corynebacterium
RT aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a
RT vaginal swab of a woman with spontaneous abortion.";
RL BMC Genomics 11:91-91(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00242};
CC -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC {ECO:0000255|HAMAP-Rule:MF_00242}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00242}.
CC -!- SIMILARITY: Belongs to the arginine deiminase family.
CC {ECO:0000255|HAMAP-Rule:MF_00242}.
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DR EMBL; CP001601; ACP32201.1; -; Genomic_DNA.
DR RefSeq; WP_010189296.1; NZ_ACLH01000059.1.
DR AlphaFoldDB; C3PEE7; -.
DR SMR; C3PEE7; -.
DR STRING; 548476.cauri_0604; -.
DR PRIDE; C3PEE7; -.
DR EnsemblBacteria; ACP32201; ACP32201; cauri_0604.
DR GeneID; 31923225; -.
DR KEGG; car:cauri_0604; -.
DR eggNOG; COG2235; Bacteria.
DR HOGENOM; CLU_052662_0_0_11; -.
DR OMA; WPARHDE; -.
DR OrthoDB; 592329at2; -.
DR UniPathway; UPA00254; UER00364.
DR Proteomes; UP000002077; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR HAMAP; MF_00242; Arg_deiminase; 1.
DR InterPro; IPR003876; Arg_deiminase.
DR PIRSF; PIRSF006356; Arg_deiminase; 1.
DR PRINTS; PR01466; ARGDEIMINASE.
PE 3: Inferred from homology;
KW Arginine metabolism; Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..415
FT /note="Arginine deiminase"
FT /id="PRO_1000204475"
FT ACT_SITE 403
FT /note="Amidino-cysteine intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00242"
SQ SEQUENCE 415 AA; 45365 MW; BA3FE867B5619B0E CRC64;
MAASPLGVWS EVGKLHQVMV CAPGLAHERL TPSNCAELLF DDVLWVDEAK KHHAEFVAEL
RSYDVEVLEM HKLLEETLDT PGGRDFILDY KLLDRNVGAG IGGELRHWFN EMPTARLAEL
LIGGLPFAEI PKGLGHGTID AMREVYGPSA FALRPLPNTQ YARDNSAWIY GGVSLNPMRM
PARHQETLLT RAIYNYHPRF AQADFKFWYG NTDEEPGLAA LEGGDIMPIG KGIVLVGMGE
RTTWQGVSQL AMRLFEEGAA TKVIIAAMAK ERASMHLDTV LTFLDADKVT AYPKVVDTIR
PIVLHPSTST APFDVELPTE SFLEVVAKAL GIGAFEVIET GGDTYAAARE QWDDANNVVA
IEPGVVVAYD RNKHTNAKLR AAGVEVVEIG SAELGRGRGG GHCMTCPIVR EAVDY
