ID   ARCA_HAEIN              Reviewed;         236 AA.
AC   P44918;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Aerobic respiration control protein ArcA homolog;
GN   Name=arcA; OrderedLocusNames=HI_0884;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Member of the two-component regulatory system ArcB/ArcA.
CC       Represses a wide variety of aerobic enzymes under anaerobic conditions
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by ArcB. {ECO:0000250}.
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DR   EMBL; L42023; AAC22542.1; -; Genomic_DNA.
DR   PIR; I64099; I64099.
DR   RefSeq; NP_439045.1; NC_000907.1.
DR   RefSeq; WP_005651417.1; NC_000907.1.
DR   AlphaFoldDB; P44918; -.
DR   SMR; P44918; -.
DR   STRING; 71421.HI_0884; -.
DR   PRIDE; P44918; -.
DR   EnsemblBacteria; AAC22542; AAC22542; HI_0884.
DR   KEGG; hin:HI_0884; -.
DR   PATRIC; fig|71421.8.peg.926; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_4_6; -.
DR   OMA; VWGWDFG; -.
DR   PhylomeDB; P44918; -.
DR   BioCyc; HINF71421:G1GJ1-924-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:CACAO.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Repressor; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..236
FT                   /note="Aerobic respiration control protein ArcA homolog"
FT                   /id="PRO_0000081012"
FT   DOMAIN          5..118
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        133..233
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   236 AA;  27424 MW;  3FB2AE2980E27F01 CRC64;
     MTTPKILVVE DEIVTRNTLK GIFEAEGYDV FEAENGVEMH HILANHNINL VVMDINLPGK
     NGLLLARELR EELSLPLIFL TGRDNEVDKI LGLEIGADDY LTKPFNPREL TIRARNLLHR
     AMPHQEKENT FGREFYRFNG WKLDLNSHSL ITPEGQEFKL PRSEFRAMLH FCENPGKLQT
     REELLKKMTG RELKPQDRTV DVTIRRIRKH FEDHPNTPNI IMTIHGEGYR FCGDIE