ID   ARCA_LACLA              Reviewed;         410 AA.
AC   P58013; Q9CE13;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Arginine deiminase;
DE            Short=ADI;
DE            EC=3.5.3.6;
DE   AltName: Full=Arginine dihydrolase;
DE            Short=AD;
GN   Name=arcA; OrderedLocusNames=LL2037; ORFNames=L0329;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family. {ECO:0000305}.
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DR   EMBL; AE005176; AAK06135.1; -; Genomic_DNA.
DR   PIR; E86879; E86879.
DR   RefSeq; NP_268194.1; NC_002662.1.
DR   RefSeq; WP_004254504.1; NC_002662.1.
DR   AlphaFoldDB; P58013; -.
DR   SMR; P58013; -.
DR   STRING; 272623.L0329; -.
DR   PaxDb; P58013; -.
DR   EnsemblBacteria; AAK06135; AAK06135; L0329.
DR   GeneID; 60356005; -.
DR   KEGG; lla:L0329; -.
DR   PATRIC; fig|272623.7.peg.2194; -.
DR   eggNOG; COG2235; Bacteria.
DR   HOGENOM; CLU_052662_0_1_9; -.
DR   OMA; ERATMHL; -.
DR   UniPathway; UPA00254; UER00364.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..410
FT                   /note="Arginine deiminase"
FT                   /id="PRO_0000182213"
FT   ACT_SITE        400
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   410 AA;  46043 MW;  2423EDAC384D84A3 CRC64;
     MNNGINVNSE IGKLKSVLLH RPGAEVENIT PDTMKQLLFD DIPYLKIAQK EHDFFAQTLR
     DNGAETVYIE NLATEVFEKS SETKEEFLSH LLHEAGYRPG RTYDGLTEYL TSMSTKDMVE
     KIYAGVRKNE LDIKRTALSD MAGSDAENYF YLNPLPNAYF TRDPQASMGV GMTINKMTFP
     ARQPESLITE YVMANHPRFK DTPIWRDRNH TTRIEGGDEL ILNKTTVAIG VSERTSSKTI
     QNLAKELFAN PLSTFDTVLA VEIPHNHAMM HLDTVFTMIN HDQFTVFPGI MDGAGNINVF
     ILRPGKDDEV EIEHLTDLKA ALKKVLNLSE LDLIECGAGD PIAAPREQWN DGSNTLAIAP
     GEIVTYDRNY VTVELLKEHG IKVHEILSSE LGRGRGGARC MSQPLWREDL