ID   ARCA_LATSK              Reviewed;         409 AA.
AC   O53088;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Arginine deiminase;
DE            Short=ADI;
DE            EC=3.5.3.6;
DE   AltName: Full=Arginine dihydrolase;
DE            Short=AD;
GN   Name=arcA;
OS   Latilactobacillus sakei (Lactobacillus sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=1599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9696763; DOI=10.1128/jb.180.16.4154-4159.1998;
RA   Zuniga M., Champomier-Verges M.-C., Zagorec M., Perez-Martinez G.;
RT   "Structural and functional analysis of the gene cluster encoding the
RT   enzymes of the arginine deiminase pathway of Lactobacillus sakei.";
RL   J. Bacteriol. 180:4154-4159(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family. {ECO:0000305}.
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DR   EMBL; AJ001330; CAA04682.1; -; Genomic_DNA.
DR   PIR; T46741; T46741.
DR   AlphaFoldDB; O53088; -.
DR   SMR; O53088; -.
DR   UniPathway; UPA00254; UER00364.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase.
FT   CHAIN           1..409
FT                   /note="Arginine deiminase"
FT                   /id="PRO_0000182215"
FT   ACT_SITE        399
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   409 AA;  45914 MW;  B2703702B3382DB5 CRC64;
     MTSPIHVNSE IGKLKTVLLK RPGKEVENIT PDIMYRLLFD DIPYLPTIQK EHDQFAQTLR
     DNGVEVLYLE NLAAEAIDAG DVKEAFLDKM LNESHIKSPQ VQAALKDYLI SMATLDMVEK
     IMAGVRTNEI DIKSKALIDV SADDDYPFYM DPMPNLYFTR DPAASMGDGL TINKMTFEAR
     QRESMFMEVI MQHHPRFANQ GAQVWRDRDH IDRMEGGDEL ILSDKVLAIG ISQRTSAQSI
     EELAKVLFAN HSGFEKILAI KIPHKHAMMH LDTVFTMIDY DKFTIHPGIQ GAGGMVDTYI
     LEPGNNDEIK ITHQTDLEKV LRDALEVPEL TLIPCGGGDA VVAPREQWND GSNTLAIAPG
     VVVTYDRNYV SNENLRQYGI KVIEVPSSEL SRGRGGPRCM SMPLVRRKT