ID   ARCA_LATSS              Reviewed;         411 AA.
AC   Q38YQ6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Arginine deiminase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=ADI {ECO:0000255|HAMAP-Rule:MF_00242};
DE            EC=3.5.3.6 {ECO:0000255|HAMAP-Rule:MF_00242};
DE   AltName: Full=Arginine dihydrolase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=AD {ECO:0000255|HAMAP-Rule:MF_00242};
GN   Name=arcA {ECO:0000255|HAMAP-Rule:MF_00242}; OrderedLocusNames=LCA_0370;
OS   Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei
OS   subsp. sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=314315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23K;
RX   PubMed=16273110; DOI=10.1038/nbt1160;
RA   Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M.,
RA   Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V.,
RA   Zagorec M.;
RT   "The complete genome sequence of the meat-borne lactic acid bacterium
RT   Lactobacillus sakei 23K.";
RL   Nat. Biotechnol. 23:1527-1533(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00242};
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
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DR   EMBL; CR936503; CAI54671.1; -; Genomic_DNA.
DR   RefSeq; WP_011374079.1; NC_007576.1.
DR   AlphaFoldDB; Q38YQ6; -.
DR   SMR; Q38YQ6; -.
DR   STRING; 314315.LCA_0370; -.
DR   PRIDE; Q38YQ6; -.
DR   EnsemblBacteria; CAI54671; CAI54671; LCA_0370.
DR   KEGG; lsa:LCA_0370; -.
DR   eggNOG; COG2235; Bacteria.
DR   HOGENOM; CLU_052662_0_1_9; -.
DR   OMA; ERATMHL; -.
DR   OrthoDB; 592329at2; -.
DR   BioCyc; LSAK314315:LCA_RS01765-MON; -.
DR   UniPathway; UPA00254; UER00364.
DR   Proteomes; UP000002707; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..411
FT                   /note="Arginine deiminase"
FT                   /id="PRO_1000005715"
FT   ACT_SITE        399
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00242"
SQ   SEQUENCE   411 AA;  46070 MW;  B7C2D21FA4970339 CRC64;
     MTSPIHVNSE IGKLKTVLLK RPGKEVENIT PDIMYRLLFD DIPYLPTIQK EHDQFAQTLR
     DNGVEVLYLE NLAAEAIDAG DVKEAFLDKM LNESHIKSPQ VQAALKDYLI SMATLDMVEK
     IMAGVRTNEI DIKSKALIDV SADGDYPFYM DPMPNLYFTR DPAASMGDGL TINKMTFEAR
     QRESMFMEVI MQHHPRFANQ GAQVWRDRDH IDRMEGGDEL ILSDKVLAIG ISQRTSAQSI
     EELAKVLFAN HSGFEKILAI KIPHNHAMMH LDTVFTMIDY DKFTIHPGIQ GAGGMVDTYI
     LEPGNNDEIK ITHQTDLEKV LRDALEVPEL TLIPCGGGDA VVAPREQWND GSNTLAIAPG
     VVVTYDRNYV SNENLRQYGI KVIEVPSSEL SRGRGGPRCM SMPLVREDLK K