ID   ARCA_METHO              Reviewed;         409 AA.
AC   P41141;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Arginine deiminase;
DE            Short=ADI;
DE            EC=3.5.3.6;
DE   AltName: Full=Arginine dihydrolase;
DE            Short=AD;
GN   Name=arcA;
OS   Metamycoplasma hominis (Mycoplasma hominis).
OC   Bacteria; Tenericutes; Mycoplasmoidales; Metamycoplasmataceae;
OC   Metamycoplasma.
OX   NCBI_TaxID=2098;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1522817; DOI=10.1111/j.1348-0421.1992.tb02068.x;
RA   Harasawa R., Koshimizu K., Kitagawa M., Asada K., Kato I.;
RT   "Nucleotide sequence of the arginine deiminase gene of Mycoplasma
RT   hominis.";
RL   Microbiol. Immunol. 36:661-665(1992).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family. {ECO:0000305}.
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DR   EMBL; D13314; BAA02571.1; -; Genomic_DNA.
DR   AlphaFoldDB; P41141; -.
DR   SMR; P41141; -.
DR   PRIDE; P41141; -.
DR   SABIO-RK; P41141; -.
DR   UniPathway; UPA00254; UER00364.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..409
FT                   /note="Arginine deiminase"
FT                   /id="PRO_0000182221"
FT   ACT_SITE        397
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   409 AA;  46313 MW;  73751AD5C430256C CRC64;
     MSVFDSKFNG IHVYSEIGEL ETVLVHEPGR EIDYITPARL DELLFSAILE SHDARKEHQS
     FVKIMKDRGI NVVELTDLVA ETYDLASKAA KEEFIETFLE ETVPVLTEAN KKAVRAFLLS
     KPTHEMVEFM MSGITKYELG VESENELIVD PMPNLYFTRD PFASVGNGVT IHFMRYIVRR
     RETLFARFVF RNHPKLVKTP WYYDPAMKMP IEGGDVFIYN NETLVVGVSE RTDLDTITLL
     AKNIKANKEV EFKRIVAINV PKWTNLMHLD TWLTMLDKNK FLYSPIANDV FKFWDYDLVN
     GGAEPQPQLN GLPLDKLLAS IINKEPVLIP IGGAGATEME IARETNFDGT NYLAIKPGLV
     IGYDRNEKTN AALKAAGITV LPFHGNQLSL GMGNARCMSM PLSRKDVKW