ID   ARCA_MYCA1              Reviewed;         402 AA.
AC   A0QBT9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Arginine deiminase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=ADI {ECO:0000255|HAMAP-Rule:MF_00242};
DE            EC=3.5.3.6 {ECO:0000255|HAMAP-Rule:MF_00242};
DE   AltName: Full=Arginine dihydrolase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=AD {ECO:0000255|HAMAP-Rule:MF_00242};
GN   Name=arcA {ECO:0000255|HAMAP-Rule:MF_00242}; OrderedLocusNames=MAV_1125;
OS   Mycobacterium avium (strain 104).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=243243;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=104;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00242};
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
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DR   EMBL; CP000479; ABK66469.1; -; Genomic_DNA.
DR   RefSeq; WP_009975265.1; NC_008595.1.
DR   AlphaFoldDB; A0QBT9; -.
DR   SMR; A0QBT9; -.
DR   EnsemblBacteria; ABK66469; ABK66469; MAV_1125.
DR   KEGG; mav:MAV_1125; -.
DR   HOGENOM; CLU_052662_0_1_11; -.
DR   OMA; ERATMHL; -.
DR   OrthoDB; 592329at2; -.
DR   UniPathway; UPA00254; UER00364.
DR   Proteomes; UP000001574; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase.
FT   CHAIN           1..402
FT                   /note="Arginine deiminase"
FT                   /id="PRO_0000336667"
FT   ACT_SITE        392
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00242"
SQ   SEQUENCE   402 AA;  43241 MW;  7566E4E89E54CAAF CRC64;
     MGVVELGTNS EVGALRVVIL HRPGGELLRL NPRNVDQLLF DGLPWVARAQ EEHDQFAELL
     RSRGVEVLLL SDLLTEALTH SGAARMQGVA AAVDARRLGV PLAQELSAYL RGLEPARLAQ
     VLMAGMTFNE LPADTRTDVS LVLRMHHGGD FVIDPLPNLV FTRDSSIWIG PRVVIPTLAL
     RARVREASLT DLIYAHHPRF TGVRRAYESR TAPVEGGDVL LLAPGVVAVG VGERTTPAGA
     EALARSLFDD DLAHTVLAVP IAQRRAQMHL DTVCTMVDTD TVVMYANVVD ALSAFTIQRT
     PSGVEISEAP FLEAAATAMG IDKLRVIDTG LDPVIAEREQ WDDGNNTLAL SPGVVVAYER
     NAQTNMRLQE AGIEVLTIAG SELGTGRGGP RCMSCPVARD PL