ARCA_MYCBO
ID ARCA_MYCBO Reviewed; 402 AA.
AC P63552; A0A1R3XX12; O05585; X2BGU7;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Arginine deiminase;
DE Short=ADI;
DE EC=3.5.3.6;
DE AltName: Full=Arginine dihydrolase;
DE Short=AD;
GN Name=arcA; OrderedLocusNames=BQ2027_MB1028;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the arginine deiminase family. {ECO:0000305}.
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DR EMBL; LT708304; SIT99628.1; -; Genomic_DNA.
DR RefSeq; NP_854685.1; NC_002945.3.
DR RefSeq; WP_003405169.1; NC_002945.4.
DR AlphaFoldDB; P63552; -.
DR SMR; P63552; -.
DR EnsemblBacteria; SIT99628; SIT99628; BQ2027_MB1028.
DR GeneID; 45424973; -.
DR PATRIC; fig|233413.5.peg.1120; -.
DR OMA; ERATMHL; -.
DR UniPathway; UPA00254; UER00364.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR HAMAP; MF_00242; Arg_deiminase; 1.
DR InterPro; IPR003876; Arg_deiminase.
DR PIRSF; PIRSF006356; Arg_deiminase; 1.
DR PRINTS; PR01466; ARGDEIMINASE.
DR TIGRFAMs; TIGR01078; arcA; 1.
PE 3: Inferred from homology;
KW Arginine metabolism; Cytoplasm; Hydrolase.
FT CHAIN 1..402
FT /note="Arginine deiminase"
FT /id="PRO_0000182220"
FT ACT_SITE 392
FT /note="Amidino-cysteine intermediate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 402 AA; 43089 MW; 16E5B4BEAA1745D2 CRC64;
MGVELGSNSE VGALRVVILH RPGAELRRLT PRNTDQLLFD GLPWVSRAQD EHDEFAELLA
SRGAEVLLLS DLLTEALHHS GAARMQGIAA AVDAPRLGLP LAQELSAYLR SLDPGRLAHV
LTAGMTFNEL PSDTRTDVSL VLRMHHGGDF VIEPLPNLVF TRDSSIWIGP RVVIPSLALR
ARVREASLTD LIYAHHPRFT GVRRAYESRT APVEGGDVLL LAPGVVAVGV GERTTPAGAE
ALARSLFDDD LAHTVLAVPI AQQRAQMHLD TVCTMVDTDT MVMYANVVDT LEAFTIQRTP
DGVTIGDAAP FAEAAAKAMG IDKLRVIHTG MDPVVAEREQ WDDGNNTLAL APGVVVAYER
NVQTNARLQD AGIEVLTIAG SELGTGRGGP RCMSCPAARD PL