ID   ARCA_MYCCT              Reviewed;         403 AA.
AC   Q2ST29;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Arginine deiminase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=ADI {ECO:0000255|HAMAP-Rule:MF_00242};
DE            EC=3.5.3.6 {ECO:0000255|HAMAP-Rule:MF_00242};
DE   AltName: Full=Arginine dihydrolase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=AD {ECO:0000255|HAMAP-Rule:MF_00242};
GN   Name=arcA {ECO:0000255|HAMAP-Rule:MF_00242}; OrderedLocusNames=MCAP_0089;
OS   Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343
OS   / NCTC 10154).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=340047;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=California kid / ATCC 27343 / NCTC 10154;
RA   Glass J.I., Lartigue C., Pfannkoch C., Baden-Tillson H., Smith H.O.,
RA   Venter J.C., Roske K., Wise K.S., Calcutt M.J., Nelson W.C., Nierman W.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00242};
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
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DR   EMBL; CP000123; ABC01474.1; -; Genomic_DNA.
DR   RefSeq; WP_011386989.1; NC_007633.1.
DR   AlphaFoldDB; Q2ST29; -.
DR   SMR; Q2ST29; -.
DR   EnsemblBacteria; ABC01474; ABC01474; MCAP_0089.
DR   GeneID; 23778957; -.
DR   KEGG; mcp:MCAP_0089; -.
DR   HOGENOM; CLU_052662_0_1_14; -.
DR   OMA; ERATMHL; -.
DR   OrthoDB; 592329at2; -.
DR   PhylomeDB; Q2ST29; -.
DR   UniPathway; UPA00254; UER00364.
DR   Proteomes; UP000001928; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase.
FT   CHAIN           1..403
FT                   /note="Arginine deiminase"
FT                   /id="PRO_0000336669"
FT   ACT_SITE        388
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00242"
SQ   SEQUENCE   403 AA;  46587 MW;  E026DCF8FC10AC15 CRC64;
     MEKKINVFSE IGTLKTVLVH RPGDEIENLT PELLERLLFD DVPFKDVAVK EHDAFTKIMR
     DNGVEVLYIE KLAAETLDQH PDLREKFIDQ FISEANIEDK YKEKYRDFIS SLDNYRMIKK
     MIAGTKKLEL GIDEGYKAYP FIADPLPNVL FQRDPFSSVG FGITMNRMWS VTRNRETIFP
     DLVFKHHNRF ANQVPYYYER DWKEETIEGG DILVLNKETL IIGVTQRTTL KAIEKFSERL
     FNDPESSYSK VIALDLPKSR AFMHLDTVFT NIDYDKFIAH PLIFDCIDEF KIYEVSKQGT
     KEVKKTLIEL LSDAAGREVQ IIRCGGNDVV GASREQWNDG TNVVALRPGK VIAYERNWIT
     IDLLRKAGVE VLTIASSELS RGRGGPRCMT MPLWREDLQE IKR