ID   ARCA_MYCPN              Reviewed;         404 AA.
AC   P75475; P75474;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Putative arginine deiminase;
DE            Short=ADI;
DE            EC=3.5.3.6;
DE   AltName: Full=Arginine dihydrolase;
DE            Short=AD;
GN   Name=arcA; OrderedLocusNames=MPN_304/MPN_305; ORFNames=MP531/MP532;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB96179.1; Type=Frameshift; Note=Produces two separate ORFs.; Evidence={ECO:0000305};
CC       Sequence=AAB96180.1; Type=Frameshift; Note=Produces two separate ORFs.; Evidence={ECO:0000305};
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DR   EMBL; U00089; AAB96180.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; U00089; AAB96179.1; ALT_FRAME; Genomic_DNA.
DR   PIR; S73857; S73857.
DR   PIR; S73858; S73858.
DR   AlphaFoldDB; P75475; -.
DR   SMR; P75475; -.
DR   IntAct; P75475; 1.
DR   STRING; 272634.MPN_305; -.
DR   EnsemblBacteria; AAB96179; AAB96179; MPN_305.
DR   EnsemblBacteria; AAB96180; AAB96180; MPN_304.
DR   KEGG; mpn:MPN_304; -.
DR   KEGG; mpn:MPN_305; -.
DR   HOGENOM; CLU_052662_1_0_14; -.
DR   UniPathway; UPA00254; UER00364.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..404
FT                   /note="Putative arginine deiminase"
FT                   /id="PRO_0000182222"
FT   ACT_SITE        394
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   404 AA;  45479 MW;  22A99F5437A7E3BE CRC64;
     MKYNINVHSE IGQLQTVLVH TPGNEIRRIS PRRLDDLLFS AVIEPDTAIQ EHQTFCQLLQ
     EQNIEVVQLT DLTATTFDKA NATAQNQFIE TWLDQAEPKL TPEHRKVAKQ YLLEQKAKST
     LSMVRSMMGG IDKRKVAAAN TINGDFLVDP MPNLYFTRDP FASIGHGISI NRMKYLTRRR
     ETLFASFIFA NHPIIAARKF YFKPIDMGTI EGGDIFVYDQ QTVVMGLSER TTEAAINVLA
     KKIQQDSSTS FKRIFVINVP QLPNLMHLDT WLTMLDRNKF LYSPNMLAVL KAWRIDFTDP
     ALKWNEIAGD LSTILHTIIG QKPMLIPIAG ADANQTEIDI ETHFDGTNYL TIAPSVVVGY
     ARNKLTHQTL EAAGVKVIAF KGNQLSLGMG SARCMSMPLV RKPL