KTNB1_CHICK
ID KTNB1_CHICK Reviewed; 657 AA.
AC Q5ZIU8; Q204L7;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Katanin p80 WD40 repeat-containing subunit B1 {ECO:0000255|HAMAP-Rule:MF_03022};
DE Short=Katanin p80 subunit B1 {ECO:0000255|HAMAP-Rule:MF_03022};
DE AltName: Full=p80 katanin {ECO:0000255|HAMAP-Rule:MF_03022};
GN Name=KATNB1 {ECO:0000255|HAMAP-Rule:MF_03022}; ORFNames=RCJMB04_23h13;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yildiz A., Baas P.W., Karabay A.;
RT "Oscillation of brain p80 katanin during chicken development.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Participates in a complex which severs microtubules in an
CC ATP-dependent manner. May act to target the enzymatic subunit of this
CC complex to sites of action such as the centrosome. Microtubule severing
CC may promote rapid reorganization of cellular microtubule arrays and the
CC release of microtubules from the centrosome following nucleation.
CC {ECO:0000255|HAMAP-Rule:MF_03022}.
CC -!- SUBUNIT: Interacts with KATNA1. This interaction enhances the
CC microtubule binding and severing activity of KATNA1 and also targets
CC this activity to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03022}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03022}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle
CC pole {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton
CC {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000250|UniProtKB:Q9BVA0}. Note=Predominantly cytoplasmic.
CC Localized to the interphase centrosome and mitotic spindle poles.
CC {ECO:0000255|HAMAP-Rule:MF_03022}.
CC -!- SIMILARITY: Belongs to the WD repeat KATNB1 family. {ECO:0000255|HAMAP-
CC Rule:MF_03022}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG32345.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; DQ410670; ABD72238.1; -; mRNA.
DR EMBL; AJ720686; CAG32345.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001025730.2; NM_001030559.2.
DR RefSeq; XP_015147779.1; XM_015292293.1.
DR AlphaFoldDB; Q5ZIU8; -.
DR SMR; Q5ZIU8; -.
DR STRING; 9031.ENSGALP00000039652; -.
DR PaxDb; Q5ZIU8; -.
DR Ensembl; ENSGALT00000073460; ENSGALP00000057300; ENSGALG00000034373.
DR GeneID; 415631; -.
DR KEGG; gga:415631; -.
DR CTD; 10300; -.
DR VEuPathDB; HostDB:geneid_415631; -.
DR eggNOG; KOG0267; Eukaryota.
DR GeneTree; ENSGT00940000157918; -.
DR HOGENOM; CLU_007811_0_0_1; -.
DR InParanoid; Q5ZIU8; -.
DR OMA; TYADIPN; -.
DR OrthoDB; 425951at2759; -.
DR PhylomeDB; Q5ZIU8; -.
DR PRO; PR:Q5ZIU8; -.
DR Proteomes; UP000000539; Chromosome 11.
DR Bgee; ENSGALG00000034373; Expressed in testis and 13 other tissues.
DR ExpressionAtlas; Q5ZIU8; baseline and differential.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0008352; C:katanin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; ISS:UniProtKB.
DR GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0051013; P:microtubule severing; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03022; Katanin_p80_B1; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR028021; Katanin_C-terminal.
DR InterPro; IPR026962; KTNB1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF13925; Katanin_con80; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..657
FT /note="Katanin p80 WD40 repeat-containing subunit B1"
FT /id="PRO_0000051052"
FT REPEAT 18..58
FT /note="WD 1"
FT REPEAT 61..100
FT /note="WD 2"
FT REPEAT 103..142
FT /note="WD 3"
FT REPEAT 145..184
FT /note="WD 4"
FT REPEAT 187..226
FT /note="WD 5"
FT REPEAT 229..269
FT /note="WD 6"
FT REGION 318..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 44
FT /note="R -> Q (in Ref. 2; CAG32345)"
FT /evidence="ECO:0000305"
FT CONFLICT 347
FT /note="Q -> QS (in Ref. 2; CAG32345)"
FT /evidence="ECO:0000305"
FT CONFLICT 359
FT /note="S -> N (in Ref. 1; ABD72238)"
FT /evidence="ECO:0000305"
FT CONFLICT 431
FT /note="K -> T (in Ref. 1; ABD72238)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 657 AA; 72738 MW; 0FB994B5A912B828 CRC64;
MAAAVVTKTA WKLQEIVAHS SNVSSLVLGK STGRLLATGG DDCRVNVWSV NKPNCVMSLT
GHTTPIESLQ ISAKEELIVA GSQSGSIRVW DLEAAKILRT LLGHKANICS LDFHPYGSFV
ASGSLDTDIK LWDVRRKGCI FKYKSHTQAV RCLRFSPDGK WLASAADDHT VKLWDLTAGK
VMFEFTGHSG PVNVVEFHPS EYLLASGSSD RTIRFWDLEK FHVVSCIEEE ATPVRCILFN
PDGCCLYGGF QDSLRVYGWE PERCFDVVVV NWGKVADLSV CHNQLIGVSF AQSTVSSFVV
DLSRVTKSGS VPHGLLRNNE LLAQPTPTGS SLRRSYDRPS TSCSKPQRVK HSSESERRSP
SSEEDRDEKE SKAEIQNPED YKEIFQPRNA ISRTPPHINE PFPAPPEDEP ITAKEAVKPN
QPVEVQTPLP KQELPETFQR PPIASSTPMP RAEPSVIPAA RNEPIGLKAS DFLPALKNQS
QAELTDEEIM SQIRKGHKTV CMVLTSRHKN LDTVRAVWST SDMKNSVDAA VATNDLSVVV
DLLNIVNQTA SLWKLDLCTV VLPQIEKLLQ SKYESYVQTG CTSLKLILQR FLPLITDILA
APPSVGVDIT REERLHKCRL CYKQLKNISN IVKNKSGLSG RHGSAFRELH LLMAVLE
