KTNB1_XENTR
ID KTNB1_XENTR Reviewed; 655 AA.
AC Q6NVM2;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Katanin p80 WD40 repeat-containing subunit B1 {ECO:0000255|HAMAP-Rule:MF_03022};
DE Short=Katanin p80 subunit B1 {ECO:0000255|HAMAP-Rule:MF_03022};
DE AltName: Full=p80 katanin {ECO:0000255|HAMAP-Rule:MF_03022};
GN Name=katnb1; ORFNames=TEgg076g13.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in a complex which severs microtubules in an
CC ATP-dependent manner. May act to target the enzymatic subunit of this
CC complex to sites of action such as the centrosome. Microtubule severing
CC may promote rapid reorganization of cellular microtubule arrays and the
CC release of microtubules from the centrosome following nucleation.
CC {ECO:0000255|HAMAP-Rule:MF_03022}.
CC -!- SUBUNIT: Interacts with katna1. This interaction enhances the
CC microtubule binding and severing activity of katna1 and also targets
CC this activity to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03022}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03022}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle
CC pole {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton
CC {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000250|UniProtKB:Q9BVA0}. Note=Predominantly cytoplasmic.
CC Localized to the interphase centrosome and mitotic spindle poles.
CC {ECO:0000255|HAMAP-Rule:MF_03022}.
CC -!- SIMILARITY: Belongs to the WD repeat KATNB1 family. {ECO:0000255|HAMAP-
CC Rule:MF_03022}.
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DR EMBL; CR926306; CAJ82237.1; -; mRNA.
DR EMBL; BC067983; AAH67983.1; -; mRNA.
DR RefSeq; NP_998874.1; NM_213709.3.
DR RefSeq; XP_012816244.1; XM_012960790.2.
DR RefSeq; XP_012816245.1; XM_012960791.2.
DR RefSeq; XP_012816246.1; XM_012960792.2.
DR AlphaFoldDB; Q6NVM2; -.
DR SMR; Q6NVM2; -.
DR PaxDb; Q6NVM2; -.
DR DNASU; 407924; -.
DR GeneID; 407924; -.
DR KEGG; xtr:407924; -.
DR CTD; 10300; -.
DR Xenbase; XB-GENE-998271; katnb1.
DR eggNOG; KOG0267; Eukaryota.
DR HOGENOM; CLU_007811_3_0_1; -.
DR InParanoid; Q6NVM2; -.
DR OrthoDB; 425951at2759; -.
DR PhylomeDB; Q6NVM2; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000025041; Expressed in egg cell and 13 other tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0008352; C:katanin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; ISS:UniProtKB.
DR GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0051013; P:microtubule severing; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 2.
DR HAMAP; MF_03022; Katanin_p80_B1; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR028021; Katanin_C-terminal.
DR InterPro; IPR026962; KTNB1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF13925; Katanin_con80; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..655
FT /note="Katanin p80 WD40 repeat-containing subunit B1"
FT /id="PRO_0000270749"
FT REPEAT 18..58
FT /note="WD 1"
FT REPEAT 61..100
FT /note="WD 2"
FT REPEAT 103..142
FT /note="WD 3"
FT REPEAT 145..184
FT /note="WD 4"
FT REPEAT 187..226
FT /note="WD 5"
FT REPEAT 229..269
FT /note="WD 6"
FT REGION 316..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 71568 MW; 1CB55CDDA7ED52D9 CRC64;
MATPSPTKTT WKLQEIVAHG SSVSSVVLGK SSGRLVATGG DDCRVNLWSV NKPNCIMSLT
GHTTPVESVR FNNAEELIVA GSQSGSLRVW DLEAAKILRT LMGHKANVCS LDFHPYGDFV
ASGSLDTNIK LWDVRRKGCV FRYKGHTQAV RCLRFSPDGK WLASASDDHS VKLWDLTAGK
MMAELSEHKG PVNIIEFHPN EYLLASGSAD RTVRFWDLEK FQLIGCTEGE TIPVRAILFS
SDGGCIFCGG RDALRVYGWE PDQCFDTVPV GWGKVCDLAI CNKQLIGVSS AQSTISSFVV
DLTRVKMTGC APQGPVPAEM PISQPAPAGT SLRRIYERPS TTCSKPKRVS PTSDDEEKES
RAEIQNPEDY KEIFQPKNAI SRTPPRNSEP FPAPPEDDTS ILKEPVAPIP DVVTPATSNK
NNTEQLQRPP VAASTPIVCQ EPSPVPAPQS KPPVISAARN EPIGLKAADF LPAVKTSSPT
EVVDDEAVSQ IRKGHDTMCM VLTSRMRNLD TVRAVWSSGD IKTSIDSAVA INDLSVVVDL
LNIINQKASL WKLDLCLTVL PQIEKMLQSK YESYVQTGCI SLKLILQRFL PLITDILAAP
PSVGVDISRE ERLSKCKLCY KQLRILSPLV KSKASQSGRY GSAFRELHLL MSGLE
