ID   KTRD_BACSU              Reviewed;         449 AA.
AC   O31658;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Ktr system potassium uptake protein D;
DE            Short=K(+)-uptake protein KtrD;
GN   Name=ktrD; Synonyms=ykrM; OrderedLocusNames=BSU13500;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=12562800; DOI=10.1128/jb.185.4.1289-1298.2003;
RA   Holtmann G., Bakker E.P., Uozumi N., Bremer E.;
RT   "KtrAB and KtrCD: two K+ uptake systems in Bacillus subtilis and their role
RT   in adaptation to hypertonicity.";
RL   J. Bacteriol. 185:1289-1298(2003).
CC   -!- FUNCTION: Integral membrane subunit of the KtrCD potassium uptake
CC       transporter. The 2 major potassium transporter complexes KtrAB and
CC       KtrCD confer resistance to both suddenly imposed and prolonged osmotic
CC       stress. {ECO:0000269|PubMed:12562800}.
CC   -!- SUBUNIT: Homodimer. Part of the KtrCD complex formed by an octameric
CC       catalytic ring of KtrC and a membrane associated dimer of KtrD forming
CC       a potassium channel (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Impaired potassium uptake.
CC       {ECO:0000269|PubMed:12562800}.
CC   -!- SIMILARITY: Belongs to the TrkH potassium transport family. Ktr (TC
CC       2.A.38.4) subfamily. {ECO:0000305}.
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DR   EMBL; AL009126; CAB13223.1; -; Genomic_DNA.
DR   PIR; H69862; H69862.
DR   RefSeq; NP_389233.1; NC_000964.3.
DR   RefSeq; WP_003244672.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O31658; -.
DR   SMR; O31658; -.
DR   STRING; 224308.BSU13500; -.
DR   TCDB; 2.A.38.4.4; the k(+) transporter (trk) family.
DR   PaxDb; O31658; -.
DR   PRIDE; O31658; -.
DR   EnsemblBacteria; CAB13223; CAB13223; BSU_13500.
DR   GeneID; 939342; -.
DR   KEGG; bsu:BSU13500; -.
DR   PATRIC; fig|224308.179.peg.1465; -.
DR   eggNOG; COG0168; Bacteria.
DR   InParanoid; O31658; -.
DR   OMA; GSMNHFS; -.
DR   PhylomeDB; O31658; -.
DR   BioCyc; BSUB:BSU13500-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003445; Cat_transpt.
DR   Pfam; PF02386; TrkH; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..449
FT                   /note="Ktr system potassium uptake protein D"
FT                   /id="PRO_0000360620"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        411..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   449 AA;  49425 MW;  0E13FBCEF3B5CBDF CRC64;
     MRLKFGKLIQ ALSPAQLIAL YYFLAVTVAV ILLSLPAAHK PGADWTFIDA LFTAVSSVSV
     TGLTVVDTAD TFSTIGIFIL AFVLQFGGIG IMTLGTFIWL IMGKRIGLKE RKLIMVDQNQ
     SQFSGIVNLM KQVLFLILWI EFFGGLILGT YFLTYYDSYQ EAYLHGFFAS ISATTNGGFD
     ITGNSMIPFR HDYFVQFITM LLIIFGAIGF PVLVEVKDFL FSKHRRYPFT LFTKITTITF
     GSLVLFGAIG IFALEANHAF AGKSWHDILF LSLFQSTATR SGGLATIDIS QLSDSTLFFI
     CALMFIGASP SSVGGGIRTT TFALNLLALF HFARGNKAVK VFKRELHPAD LMKSLVVTMM
     AILLVFGATL ILTITEKHSL LELLFEVCSA FGTTGLSLGI TADLSSVGKC VIMIVMFIGR
     IGILTFLYLI GRKEIEANYH YPKERVIIG