ID   KTU_AEDAE               Reviewed;         898 AA.
AC   Q0IEW8;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Protein kintoun {ECO:0000255|HAMAP-Rule:MF_03069};
DE   AltName: Full=Dynein assembly factor 2, axonemal homolog {ECO:0000255|HAMAP-Rule:MF_03069};
GN   ORFNames=AAEL007767;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Required for cytoplasmic pre-assembly of axonemal dyneins,
CC       thereby playing a central role in motility in cilia and flagella.
CC       Involved in pre-assembly of dynein arm complexes in the cytoplasm
CC       before intraflagellar transport loads them for the ciliary compartment.
CC       {ECO:0000255|HAMAP-Rule:MF_03069}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03069}.
CC   -!- SIMILARITY: Belongs to the PIH1 family. Kintoun subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03069}.
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DR   EMBL; CH477464; EAT40503.1; -; Genomic_DNA.
DR   RefSeq; XP_001658637.1; XM_001658587.1.
DR   AlphaFoldDB; Q0IEW8; -.
DR   SMR; Q0IEW8; -.
DR   STRING; 7159.AAEL007767-PA; -.
DR   GeneID; 5569576; -.
DR   KEGG; aag:5569576; -.
DR   VEuPathDB; VectorBase:AAEL007767; -.
DR   eggNOG; KOG4356; Eukaryota.
DR   HOGENOM; CLU_012715_0_0_1; -.
DR   InParanoid; Q0IEW8; -.
DR   OMA; YSIKHSH; -.
DR   OrthoDB; 943252at2759; -.
DR   PhylomeDB; Q0IEW8; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0060285; P:cilium-dependent cell motility; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03069; Kintoun; 1.
DR   InterPro; IPR034727; Kintoun.
DR   InterPro; IPR012981; PIH1_N.
DR   InterPro; IPR041442; PIH1D1/2/3_CS-like.
DR   Pfam; PF08190; PIH1; 1.
DR   Pfam; PF18201; PIH1_CS; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..898
FT                   /note="Protein kintoun"
FT                   /id="PRO_0000365802"
FT   REGION          558..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          765..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..604
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        624..680
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        782..803
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   898 AA;  101881 MW;  B9348F55D20EEFFE CRC64;
     MSNVGDKFEL SRDEFRNITQ CLGNEEFRKL FAEYCQELKD PENRKQYEEE LKLMEAERGY
     DVKFIKPLPG YVIKTVVDGK TKAFVNVCHC DLVGKPSSQC STNKRGEKGL KWSIPYAQSQ
     PRKDYDNKNV DCVVYDVVFH YDTLHLTKSN KNFRKLVTDT ALDAVEGAFH VSLDRVNLKF
     PKLQYKGVAK MTVIRQKLKN FETRRKDGLI DTLYRASEQS KITHDNSADK ENVNKQTFKS
     ASQLEYTTPA YKLIHRKEVE YHELTGELDA KLDAAIPKEL VLVIELPLLK SANQCTLNVT
     SSEVHLISDS PAKYKLEVKL PYTVLEKNGS AKFNTDETTL TVLLPVARNR RTLNDVTVSS
     NDQSMPDEMD QKPVERVKPL KEPQLVHSNA NKKIIFPKFS ANKMDNIFAF TLNVRNVDPS
     SIELQKGTDT VSCRFTNIGN GFFPCYYIFF LRFPNANITE VQHEEWDNNI ILQVVLDHGL
     IDCYYAGTNE NDLVQYSIME DITDKINKFG KEIEDDSLCI AVSKNAIKQE RKSSHLSIEI
     KTKDEIESDE GIDSALEGEL KTDQSMQEDE NPDEINTRTV EDDTKVAKEN VKKVDQETAH
     EGKKSKKNQR RKNKKRSLSE SCCDHLKVTI NNDNPKPESG NEANSFEGTG SSSEATSKQR
     KARSVSESCP ARDNNGVESD SVDNLSALIQ FNHKYKGILK RSSLQRSISE CSSIDEHYYL
     GTSVDGSSVA ESVDHTNGEL SESCRKTVRF NDAIKTKLFR SNTSILGQKK KNAKKNESKR
     RALTRRLSEG ESTDNEDKDH QTTNEAPGSV VQRDTEHDSG ISLDSDAAHP IEINADTEVQ
     NQHQNDSTKP IEINRKVEKK FIASKNNNCN VKAQFIKSKR NDSSDIEFKS DMIFDIEM