KTU_ANOGA
ID KTU_ANOGA Reviewed; 862 AA.
AC Q7Q9F6;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 4.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Protein kintoun {ECO:0000255|HAMAP-Rule:MF_03069};
DE AltName: Full=Dynein assembly factor 2, axonemal homolog {ECO:0000255|HAMAP-Rule:MF_03069};
GN ORFNames=AGAP005250;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Required for cytoplasmic pre-assembly of axonemal dyneins,
CC thereby playing a central role in motility in cilia and flagella.
CC Involved in pre-assembly of dynein arm complexes in the cytoplasm
CC before intraflagellar transport loads them for the ciliary compartment.
CC {ECO:0000255|HAMAP-Rule:MF_03069}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03069}.
CC -!- SIMILARITY: Belongs to the PIH1 family. Kintoun subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03069}.
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DR EMBL; AAAB01008900; EAA09341.4; -; Genomic_DNA.
DR RefSeq; XP_314165.4; XM_314165.4.
DR AlphaFoldDB; Q7Q9F6; -.
DR SMR; Q7Q9F6; -.
DR STRING; 7165.AGAP005250-PA; -.
DR PaxDb; Q7Q9F6; -.
DR GeneID; 1274963; -.
DR KEGG; aga:AgaP_AGAP005250; -.
DR CTD; 1274963; -.
DR VEuPathDB; VectorBase:AGAP005250; -.
DR eggNOG; KOG4356; Eukaryota.
DR HOGENOM; CLU_012715_0_0_1; -.
DR InParanoid; Q7Q9F6; -.
DR OMA; YSIKHSH; -.
DR OrthoDB; 943252at2759; -.
DR PhylomeDB; Q7Q9F6; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0060285; P:cilium-dependent cell motility; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03069; Kintoun; 1.
DR InterPro; IPR034727; Kintoun.
DR InterPro; IPR012981; PIH1_N.
DR InterPro; IPR041442; PIH1D1/2/3_CS-like.
DR Pfam; PF08190; PIH1; 1.
DR Pfam; PF18201; PIH1_CS; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..862
FT /note="Protein kintoun"
FT /id="PRO_0000365803"
FT REGION 208..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 862 AA; 96032 MW; B364DD967E4B8DA0 CRC64;
MSTKDFNISR DEFRNITRCL DNEEFRNLFM EYCTELRDNR KQYEDELSML EAQRGYDVKF
LKPSPGYVIK TIVDGKGKGF INVCQSELVQ KPTSTTGLNE DGTKGLKWSV PYAQTQPRKD
YDNKRVECTV YDVMFHPDAL HLASKNEGFR KLLNDTSLDA VEQSFKVRLD RANLRFPKLQ
YKGTPSSSVV REKLPHCDSL PKDELFDKLL PPLPNVPAPG KTGSERTTKT KNKENINRTA
AVAAAAASPG NPFYTTPEYK IVQCRDVEYG EMTNELDAKI DVTIPRELKV VITLPLLKST
AECALDVTKT TLHLVSEKPA RYKLELKLPY EVKESEGKAT FNVEARSLTV TLPVLRKRNI
TLQDINSANV SASPAKEAGK LIEEIGTIIP PAGGDQQLAR AASAPSAPEV PKKTIFPKFS
VNKMENLLAF TLNVRNVDPS TIQLDNRTDS VHCRFSNVGN GYFPCFYVFF VRFPNALVTD
VQHEEWDNNL IIQITLNTAS VSSYQAGPDE HETVEYSIME DIADKINKFG KEIEDDSLCI
AVVRQATKAS AKVKADALMS IEITKREEHG EPECDEKDGS EAEKARTLQK AKRNSRKKKK
ERSLSDSFCD HLKVIVENEA STEVAGEGAT IQSSAKPIDS PEAKARKARS ISECCPPKES
DGGEEASTMP TLTRKYKSIL KRSSYDRSIS ECSSVDDLGT SVEMARSIGE ECRKTVRFNN
SIRKQLFRSN SCILTMKKKA LKRREVKRRA DARRMSEGES TDNDEKDAHH HDDEHCSSSD
QHDEKDAIED DSGVSFDSES GDKEIAAAMK AEAIGGGGRG KAASKRKNSN KQGGAKSNGG
KKQGTDAKNI QFKSDMIFDI EI
