KTU_DROWI
ID KTU_DROWI Reviewed; 828 AA.
AC P0CU29; B4MPK3;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2016, sequence version 1.
DT 25-MAY-2022, entry version 26.
DE RecName: Full=Protein kintoun {ECO:0000255|HAMAP-Rule:MF_03069};
DE AltName: Full=Dynein assembly factor 2, axonemal homolog {ECO:0000255|HAMAP-Rule:MF_03069};
DE AltName: Full=PP1-interacting protein 20 {ECO:0000255|HAMAP-Rule:MF_03069};
GN Name=Nop17l {ECO:0000255|HAMAP-Rule:MF_03069};
GN Synonyms=Ppi20 {ECO:0000255|HAMAP-Rule:MF_03069}; ORFNames=GK27737;
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for cytoplasmic pre-assembly of axonemal dyneins,
CC thereby playing a central role in motility in cilia and flagella.
CC Involved in pre-assembly of dynein arm complexes in the cytoplasm
CC before intraflagellar transport loads them for the ciliary compartment.
CC {ECO:0000255|HAMAP-Rule:MF_03069}.
CC -!- SUBUNIT: Interacts with Pp1alpha-96A, Pp1-87B, Pp1-13C and flw.
CC {ECO:0000255|HAMAP-Rule:MF_03069}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03069}.
CC -!- SIMILARITY: Belongs to the PIH1 family. Kintoun subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03069}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDW74042.1; Type=Erroneous gene model prediction; Note=The predicted gene GK21583 has been split into 2 genes: GK21583 and GK27737.; Evidence={ECO:0000305};
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DR EMBL; CH963849; EDW74042.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_015034407.1; XM_015178921.1.
DR AlphaFoldDB; P0CU29; -.
DR SMR; P0CU29; -.
DR STRING; 7260.FBpp0250726; -.
DR EnsemblMetazoa; FBtr0416438; FBpp0374625; FBgn0279603.
DR GeneID; 26529739; -.
DR KEGG; dwi:26529739; -.
DR eggNOG; KOG2614; Eukaryota.
DR eggNOG; KOG4356; Eukaryota.
DR OrthoDB; 943252at2759; -.
DR PhylomeDB; P0CU29; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008157; F:protein phosphatase 1 binding; IEA:EnsemblMetazoa.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0060285; P:cilium-dependent cell motility; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03069; Kintoun; 1.
DR InterPro; IPR034727; Kintoun.
DR InterPro; IPR012981; PIH1_N.
DR InterPro; IPR041442; PIH1D1/2/3_CS-like.
DR Pfam; PF08190; PIH1; 1.
DR Pfam; PF18201; PIH1_CS; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..828
FT /note="Protein kintoun"
FT /id="PRO_0000365813"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..412
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..813
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..828
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0E9G3"
FT MOD_RES 759
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0E9G3"
SQ SEQUENCE 828 AA; 94728 MW; 919D355364441D47 CRC64;
MSGSTASARN KHSKGNLKHN NNKNKNNDEP IDITKDEFER IREALGKEEF RKLFFEYVDE
IQDPANRKIY EDEITQLEKE RGVEVTFIHP QPGFVVKTSI DGEQKCFINI AGSPEIARPE
SKLDINPDTG DRGLSWSIPM AQTASRDDCD AKNQQCKVFD VVFHPDALHL GQKNSQFRKC
LIDTALDAVE REYEVNLDRT NLKYPKLDYK GIARPTVIRK LSKNPTDEEL EPHPLEHSFP
TKPTAGEGEP KVLPMKVQKE QPKAPKFTEP KYSIKYSHDV DLSEYTNELD AKLQVTKPRA
LVVEIELPLL RSTAECELDV TSKSIYLLSE RAGAKYRLKL DLPYTVDDKS GRARFDTDKR
RLNIHLPVIR SNEPNLRLLS REDSGVELHS NSESPVEEEE DGEDEIEAEE EEEEVKTKVK
PTSNPPSFLK SSLHYQLPGK FDCNLLDNCM AFTLHVANVQ PDSIEYVQEK RSLHLQFASM
GNGYYPTHYA FYVALPAKES QLIIENVEAE AWDNNVILKL DLNKSSESIE SYLAGLDDQD
LQDYAIHGQF KALKEAPVQE DKPGDIQFKR NDQEPSLEIT VSGLNAVEQQ EREEGEIEEA
EEQQHKKSAS KKQRGKRNKK ERSLSESACV SLPTSVDSQP MATLKLPQRK QRSFSECHEQ
QHHHHRGILK RFSRYDGNDS CSSIDDCSSS YPCSVEASRS FGGIPEEDSS LSESCKKTVR
FNDHIMKQVF RLDSSILGQR KKNQKRRDCK LRAQQRRLSE GDSADYEEST ANKTQYCKYN
KKHHHHHDSG LDLTRHNKKR ELAEEADNKN SLMFEMDDDD DDEDEDLI
