ID   KTU_DROYA               Reviewed;         846 AA.
AC   B4P238;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein kintoun {ECO:0000255|HAMAP-Rule:MF_03069};
DE   AltName: Full=Dynein assembly factor 2, axonemal homolog {ECO:0000255|HAMAP-Rule:MF_03069};
DE   AltName: Full=PP1-interacting protein 20 {ECO:0000255|HAMAP-Rule:MF_03069};
GN   Name=Nop17l {ECO:0000255|HAMAP-Rule:MF_03069};
GN   Synonyms=Ppi20 {ECO:0000255|HAMAP-Rule:MF_03069}; ORFNames=GE23618;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for cytoplasmic pre-assembly of axonemal dyneins,
CC       thereby playing a central role in motility in cilia and flagella.
CC       Involved in pre-assembly of dynein arm complexes in the cytoplasm
CC       before intraflagellar transport loads them for the ciliary compartment.
CC       {ECO:0000255|HAMAP-Rule:MF_03069}.
CC   -!- SUBUNIT: Interacts with Pp1alpha-96A, Pp1-87B, Pp1-13C and flw.
CC       {ECO:0000255|HAMAP-Rule:MF_03069}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03069}.
CC   -!- SIMILARITY: Belongs to the PIH1 family. Kintoun subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03069}.
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DR   EMBL; CM000157; EDW89239.1; -; Genomic_DNA.
DR   RefSeq; XP_002089527.1; XM_002089491.2.
DR   RefSeq; XP_015054345.1; XM_015198859.1.
DR   AlphaFoldDB; B4P238; -.
DR   SMR; B4P238; -.
DR   STRING; 7245.FBpp0268628; -.
DR   EnsemblMetazoa; FBtr0270136; FBpp0268628; FBgn0240791.
DR   EnsemblMetazoa; FBtr0402667; FBpp0361498; FBgn0240791.
DR   GeneID; 6528481; -.
DR   KEGG; dya:Dyak_GE23618; -.
DR   eggNOG; KOG4356; Eukaryota.
DR   HOGENOM; CLU_012715_0_0_1; -.
DR   OMA; YSIKHSH; -.
DR   OrthoDB; 943252at2759; -.
DR   PhylomeDB; B4P238; -.
DR   Proteomes; UP000002282; Chromosome 2L.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IEA:EnsemblMetazoa.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0060285; P:cilium-dependent cell motility; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03069; Kintoun; 1.
DR   InterPro; IPR034727; Kintoun.
DR   InterPro; IPR012981; PIH1_N.
DR   InterPro; IPR041442; PIH1D1/2/3_CS-like.
DR   Pfam; PF08190; PIH1; 1.
DR   Pfam; PF18201; PIH1_CS; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphoprotein.
FT   CHAIN           1..846
FT                   /note="Protein kintoun"
FT                   /id="PRO_0000365814"
FT   REGION          216..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          372..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          574..631
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          762..846
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..404
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        581..607
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        774..793
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        794..811
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         380
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q0E9G3"
FT   MOD_RES         780
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q0E9G3"
SQ   SEQUENCE   846 AA;  95547 MW;  274506B0F2AF0C16 CRC64;
     MSASAARSRN KQSKLRDDEQ LDISKDEFNR IQEAFGREEF RKLFFDYVEE IQDPENRKIY
     EEEITQLEKE RGVEVRFIHP KPGFVIKTAL DGELKCFINI AGSEEIERPK NEVATDPSSG
     SRGLSWSIPM AQTSSRDDCD AKNNHCKVFD VVFHPDALHL AKRNKQFRQC LIDTALDAVE
     REYKVSLDRA NLKFPKLDYK GIPRPTVIRK LADNPTAEEQ EPHPLAHMFP TKPPAPGKPE
     PRVLPMKTKP TPVPEFTVPR YSIKHSHDVD LSEYTDELDA KLHVTVPRSL VVEIELPLLR
     STAECQLDVT SKSVYLFSER QGAKYRLKLD LPFSVDDKAG QARFDTDMRR LSITLPVVRK
     STKEEAQMHD TLRHFSREDS GVELHSNSES PVEEDPDGEL SDSKADISEI SSPTTATVRL
     ANSPFLKNSV HYQLPSKFDC NVLDNVMAFV LHVPNVQPDS IEQLREQRSL HLQFATIGSG
     YYPTHYAFYV ELPAEHEDSA IESVEAEAWD NNVVLKLCLS SQSETPASYL AGLDATELKE
     YPVHGQYNVK SSGKANAKEN APLDVKFVHN QEGQALKVTI RPGTKEEEEK GNQDQEPESD
     KQHQQQSQNK KAGKKQRKRN KKERSLSESA CADMIFQEPL AKNPELQPKT MFKFPSQRKQ
     RSYSECNDSI GGSHRGILKR FSRYGPRPSM SDSCSSIDDC SSYSCSVDAS GTSLFSHSFG
     GIPEEDRSDA GLSESCKKTV RFNDHIMKQV FRLDSSILGQ RKKNQKRRDL KLRAQQRRLS
     EGDSVDYEET RGSALKQQEN QSRNCNKPNG GSVLHDSGLD LTGAPGAHSN HNESEAKNAL
     MFEMDD