ID   KTU_XENTR               Reviewed;         785 AA.
AC   Q0P4V4;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Protein kintoun {ECO:0000255|HAMAP-Rule:MF_03069};
DE   AltName: Full=Dynein assembly factor 2, axonemal {ECO:0000255|HAMAP-Rule:MF_03069};
GN   Name=dnaaf2 {ECO:0000255|HAMAP-Rule:MF_03069};
GN   Synonyms=ktu {ECO:0000255|HAMAP-Rule:MF_03069};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for cytoplasmic pre-assembly of axonemal dyneins,
CC       thereby playing a central role in motility in cilia and flagella.
CC       Involved in pre-assembly of dynein arm complexes in the cytoplasm
CC       before intraflagellar transport loads them for the ciliary compartment.
CC       {ECO:0000255|HAMAP-Rule:MF_03069}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03069}.
CC       Dynein axonemal particle {ECO:0000250|UniProtKB:B1H1W9}. Note=Localizes
CC       in the apical cytoplasm around the gamma-tubulin-positive
CC       pericentriolar region, not in the cilia. {ECO:0000255|HAMAP-
CC       Rule:MF_03069}.
CC   -!- SIMILARITY: Belongs to the PIH1 family. Kintoun subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03069}.
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DR   EMBL; BC121889; AAI21890.1; -; mRNA.
DR   RefSeq; NP_001072474.1; NM_001079006.1.
DR   AlphaFoldDB; Q0P4V4; -.
DR   SMR; Q0P4V4; -.
DR   STRING; 8364.ENSXETP00000020006; -.
DR   PaxDb; Q0P4V4; -.
DR   PRIDE; Q0P4V4; -.
DR   GeneID; 779929; -.
DR   KEGG; xtr:779929; -.
DR   CTD; 55172; -.
DR   Xenbase; XB-GENE-5887533; dnaaf2.
DR   eggNOG; KOG4356; Eukaryota.
DR   InParanoid; Q0P4V4; -.
DR   OrthoDB; 943252at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; IBA:GO_Central.
DR   GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
DR   GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IBA:GO_Central.
DR   HAMAP; MF_03069; Kintoun; 1.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR034727; Kintoun.
DR   InterPro; IPR012981; PIH1_N.
DR   InterPro; IPR041442; PIH1D1/2/3_CS-like.
DR   Pfam; PF08190; PIH1; 1.
DR   Pfam; PF18201; PIH1_CS; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..785
FT                   /note="Protein kintoun"
FT                   /id="PRO_0000365801"
FT   REGION          622..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          719..749
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        622..642
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..681
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        682..698
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   785 AA;  88104 MW;  791DAB8A0C613E5A CRC64;
     MAAKLQDLEL SSEEVDRFSK AFKDPTFREM FIQYAEEISD PENRKKYEQE IYKMENERGM
     DIKFIHPKPG YVLLSSVNGV QKCYLNICSN DLIQKPEFKP GKDGEGKAGL HWSLPYSLSP
     GRDDLSKDWS KHVIYDVVFH PDTLHIASKN GKFKGIVDST ALEAVASQFN VTLDKANVRT
     LSMKYKGVPN PSVLRKPLPE ASPKSRDLED PLCFPYPYDV PTAVGTEKKD QKRVIQKECK
     QHLVTPEQDP NVQVAATPNY TVRHRSYVDL QDFRDSRDST PSPVPKELVI TVDLPLLNSA
     AGVNLHIAGK NLSLESEKPA YKLNVKLPYA VEDNQGKAQF NKVKKQLIIT VPVIQHNILS
     LMQDHFQEAR GEKDNQNKAE HSVLNKEHTD NSGITSARGT EKLLELEEEN QFEGLASISS
     MDTGASHLPE ILPNLNTFGK EQVVNQMNED TPNVPTDNLV CPTFTCSQDP TSLTLIVHVR
     DIDENSICAD VGSNHYHIRC YRKQSRAFYD LLVTFLPHDI IISNEVSVNI SEDNVVIGLT
     KCPESFGFWK KLYFGVSGQS LQERRFVIEE NINKVLACSI PLSQVSPSIQ EHQPLIEVLE
     MTDEKTHIRL NEPKIEYVDS AEHNEQCTDH SESERDTSLE LPNVDGKDSA EQCSSQVSPC
     KHNIELGREH TSERDKEPKP TSCTAESTSG QQPNDSHLVC PGDNCAQDSN AENKMACLKS
     SVQTTQESDL DEDDMPDNSD HLQNSASSNN ILKEISSKDG SVQVISDHTT HCPFQFQNSL
     LFELD