ID   KTX20_TITSE             Reviewed;          83 AA.
AC   A0A218QXE6;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2017, sequence version 1.
DT   03-AUG-2022, entry version 6.
DE   RecName: Full=Putative potassium channel toxin Ts20 {ECO:0000303|PubMed:33181162};
DE   AltName: Full=Putative KTx {ECO:0000303|PubMed:33181162};
DE   AltName: Full=Tityustoxin-20 {ECO:0000305};
DE   Flags: Precursor;
OS   Tityus serrulatus (Brazilian scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=6887;
RN   [1] {ECO:0000312|EMBL:JAW06974.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Telson;
RX   PubMed=29561852; DOI=10.1371/journal.pone.0193739;
RA   de Oliveira U.C., Nishiyama M.Y. Jr., Dos Santos M.B.V.,
RA   Santos-da-Silva A.P., Chalkidis H.M., Souza-Imberg A., Candido D.M.,
RA   Yamanouye N., Dorce V.A.C., Junqueira-de-Azevedo I.L.M.;
RT   "Proteomic endorsed transcriptomic profiles of venom glands from Tityus
RT   obscurus and T. serrulatus scorpions.";
RL   PLoS ONE 13:e0193739-e0193739(2018).
RN   [2] {ECO:0000312|EMBL:QPD99053.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Telson;
RX   PubMed=33181162; DOI=10.1016/j.toxicon.2020.11.001;
RA   Kalapothakis Y., Miranda K., Pereira A.H., Witt A.S.A., Marani C.,
RA   Martins A.P., Leal H.G., Campos-Junior E., Pimenta A.M.C., Borges A.,
RA   Chavez-Olortegui C., Kalapothakis E.;
RT   "Novel components of Tityus serrulatus venom: a transcriptomic approach.";
RL   Toxicon 189:91-104(2021).
CC   -!- FUNCTION: Reversibly inhibits potassium channels.
CC       {ECO:0000250|UniProtKB:Q5F1N4}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29561852,
CC       ECO:0000305|PubMed:33181162}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:29561852, ECO:0000305|PubMed:33181162}.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
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DR   EMBL; GEUW01000071; JAW06974.1; -; mRNA.
DR   EMBL; MT450717; QPD99053.1; -; mRNA.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..83
FT                   /note="Putative potassium channel toxin Ts20"
FT                   /id="PRO_5013030286"
SQ   SEQUENCE   83 AA;  9947 MW;  F0AFCE0A38830A67 CRC64;
     MKLDIVLIMF VTFSTTLAQH DEREEWYPFR FGNGHVGCSN RLGMSENDFC RKLCNQDGKW
     RNSKCKEHYC YCGPQRFYRV IKL